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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00981


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00981
General rule information [?]

Accession PRU00981
Dates 05-JUL-2012 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS50888; BHLH
Name Myc-type, basic helix-loop-helix (bHLH) domain
Function Fill in
Scope(s) Eukaryota
Viruses
Retroviridae
Example(s) Q9W6C8;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.
case not <FTTag:basic>
CAUTIONContains a degenerate basic motif not likely to bind DNA.
end case

Keywords [?]

Nucleus
case <FTTag:basic>
DNA-binding
end case
Transcription
Transcription regulation

Gene Ontology [?]

GO:0005634; Cellular component:nucleus

Features [?]

From: PS50888
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="bHLH #"
REGION 15 to /note="Helix-loop-helix motif #"
case <Feature:PS50888:1-14=x(0,)-[RK]-x(0,)-[RK]-x(0,)-[RK]-x(0,)-[RK]-x(0,)>
REGION from 14 /note="Basic motif #" basic
else
REGION from 14 /note="Basic motif #; degenerate"
end case

Additional information [?]

Size range 38-115 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]