We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00983
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00983
General rule information
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| Accession | PRU00983 |
| Dates | 26-APR-2016 (Created)
06-JAN-2020 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51650; C2_DOCK |
Name | C2 DOCK-type domain |
| Function | The ~200 residue DOCK-type C2 domain is located toward the N- terminus and interacts with phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] to mediate signalling and membrane localization. |
| Scope(s) |
Eukaryota |
| Example(s) | Q8C3J5; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the DOCK family. |
Features
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| From: PS51650 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="C2 DOCK-type #" | |||||||||
Additional information
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| Size range | 150-195 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [24] All [ 24 ]
- Retrieve set of proteins with 3D structure for this domain