We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01024
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01024
General rule information
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| Accession | PRU01024 |
| Dates | 28-AUG-2013 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51687; SAM_MT_RNA_M5U |
Name | SAM-dependent methyltransferase RNA m(5)U-type domain |
| Function | RNA 5-methyluridine (m(5)U) methyltransferase |
| Scope(s) |
Bacteria Eukaryota Archaea Viruses Mimivirus |
| Example(s) | B3PL62; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.1.1.-; |
Comments
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| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. |
Keywords
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Features
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| From: PS51687 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 319 | 319 | /note="Nucleophile" | C | ||||||||
| BINDING | 194 | 194 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Q | ||||||||
| BINDING | 223 | 223 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[FY] | ||||||||
| BINDING | 244 | 244 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DE] | ||||||||
| BINDING | 292 | 292 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DN] | ||||||||
Additional information
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| Size range | 200-559 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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