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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01026


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01026
General rule information [?]

Accession PRU01026
Dates 14-OCT-2013 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51689; SAM_RNA_A_N6_MT
Name rRNA adenine N(6)-methyltransferase family
Function rRNA adenine N(6)-methyltransferase and adenine N(6), N(6)- dimethyltransferase
Scope(s) Bacteria
Eukaryota
Archaea
Example(s) P45438;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.1.1.-;

Comments [?]

SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

Keywords [?]

Methyltransferase
Transferase
S-adenosyl-L-methionine
RNA-binding

Gene Ontology [?]

GO:0000179; Molecular function:rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0031167; Biological process:rRNA methylation
GO:0003723; Molecular function:RNA binding

Cross-references [?]

PROSITE PS01131; RRNA_A_DIMETH; 1;

Features [?]

From: PS51689
Key From To Description Tag Condition FTGroup
BINDING 8 8 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 [HKN]
BINDING 10 10 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 [ILMTV]
BINDING 35 35 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 G
BINDING 56 56 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 [DE]
BINDING 81 81 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 D
BINDING 101 101 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 [ANS]

Additional information [?]

Size range 230-334 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]