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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01030


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01030
General rule information [?]

Accession PRU01030
Dates 11-NOV-2013 (Created)
22-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51693; HCV_NS2_PRO
Name Hepacivirus nonstructural protein 2 (NS2) protease domain
Function NS2 is a 217 amino acids (aa) long cysteine-protease composed of a highly hydrophobic N-terminal membrane binding domain (MBD) and a C-terminal globular and cytosolic protease domain. The HCV NS2 protease domain forms the peptidase family C18.
Scope(s) Viruses
Flaviviridae
Example(s) Q9WMX2;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + Contains:
RecName: Full=Protease NS2-3;
                 Short=p23;
                 EC=3.4.22.-;
end case

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51693
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C18 #"
ACT_SITE 50 50 /note="For protease NS2-3 activity; shared with dimeric partner" H 1
ACT_SITE 70 70 /note="For protease NS2-3 activity; shared with dimeric partner" E 1
ACT_SITE 91 91 /note="For protease NS2-3 activity; shared with dimeric partner" C 1
case <FTGroup:1>
CHAIN ? 124 /note="Protease NS2-3"
SITE 124 124+1 /note="Cleavage; by protease NS2-3"
end case

Additional information [?]

Size range 112-138 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]