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annotation rule: PRU01030 |
Accession | PRU01030 |
Dates | 11-NOV-2013 (Created) 22-NOV-2019 (Last updated, Version 6) |
Data class | Domain |
Predictors | PROSITE; PS51693; HCV_NS2_PRO |
Name | Hepacivirus nonstructural protein 2 (NS2) protease domain |
Function | NS2 is a 217 amino acids (aa) long cysteine-protease composed of a highly hydrophobic N-terminal membrane binding domain (MBD) and a C-terminal globular and cytosolic protease domain. The HCV NS2 protease domain forms the peptidase family C18. |
+ Contains: RecName: Full=Protease NS2-3; Short=p23; EC 3.4.22.-; |
From: PS51693 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Peptidase C18 # | |||||||||
ACT_SITE | 50 | 50 | For protease NS2-3 activity; shared with dimeric partner | H | 1 | |||||||
ACT_SITE | 70 | 70 | For protease NS2-3 activity; shared with dimeric partner | E | 1 | |||||||
ACT_SITE | 91 | 91 | For protease NS2-3 activity; shared with dimeric partner | C | 1 |
Size range | 112-138 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q9WMX2 (POLG_HCVCO) |
Scope | Viruses; Flaviviridae |
Comments | None |
Viruses | [33] |