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annotation rule: PRU01030

General rule information [?]

Accession PRU01030
Dates 11-NOV-2013 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51693; HCV_NS2_PRO
Name Hepacivirus nonstructural protein 2 (NS2) protease domain
Function NS2 is a 217 amino acids (aa) long cysteine-protease composed of a highly hydrophobic N-terminal membrane binding domain (MBD) and a C-terminal globular and cytosolic protease domain. The HCV NS2 protease domain forms the peptidase family C18.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ Contains: RecName: Full=Protease NS2-3; Short=p23; EC 3.4.22.-;
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.

Keywords [?]

Hydrolase
Protease
Thiol protease
end case


Features [?]

From: PS51693
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C18 #        
ACT_SITE     50     50       For protease NS2-3 activity; shared with dimeric partner     H   1
ACT_SITE     70     70       For protease NS2-3 activity; shared with dimeric partner     E   1
ACT_SITE     91     91       For protease NS2-3 activity; shared with dimeric partner     C   1
case <FTGroup:1>
CHAIN     ?     124       Protease NS2-3        
SITE     124     124+1       Cleavage; by protease NS2-3        
end case


Additional information [?]

Size range 112-138 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9WMX2 (POLG_HCVCO)
Scope
Viruses; Flaviviridae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]