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ProRule PRU01030


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01030
Accession PRU01030
Dates 11-NOV-2013 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51693; HCV_NS2_PRO
Name Hepacivirus nonstructural protein 2 (NS2) protease domain
Function NS2 is a 217 amino acids (aa) long cysteine-protease composed of a highly hydrophobic N-terminal membrane binding domain (MBD) and a C-terminal globular and cytosolic protease domain. The HCV NS2 protease domain forms the peptidase family C18.
Scope(s) Viruses
Flaviviridae
Example(s) Q9WMX2 (POLG_HCVCO);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + Contains:
RecName: Full=Protease NS2-3;
                 Short=p23;
                 EC=3.4.22.-;
end case

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004197; Molecular function:cysteine-type endopeptidase activity

Features [?]

From: PS51693
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C18 #"
ACT_SITE 50 50 /note="For protease NS2-3 activity; shared with dimeric partner" H 1
ACT_SITE 70 70 /note="For protease NS2-3 activity; shared with dimeric partner" E 1
ACT_SITE 91 91 /note="For protease NS2-3 activity; shared with dimeric partner" C 1
case <FTGroup:1>
CHAIN ? 124 /note="Protease NS2-3"
SITE 124 124+1 /note="Cleavage; by protease NS2-3"
end case

Additional information [?]

Size range 112-138 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]