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PRU01032


General rule information [?]

Accession PRU01032
Dates 20-AUG-2014 (Created)
26-JAN-2023 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51695; SEDOLISIN
Name Sedolisin domain
Function Sedolisins (serine-carboxyl peptidases) are proteolytic enzymes whose fold ressembles that of subtilisin; however they are considerably larger, with the mature catalytic domains containing approximately 375 amino acids. The defining features of these enzymes are a unique catalytic triad, Ser-Glu-Asp (SED in single-letter notation), as well as the presence of an aspartic acid residue in the oxyanion hole.

Propagated annotation [?]


Comments [?]

case <FTGroup:2>
Cofactor Ca(2+)
Note: Binds 1 Ca(2+) ion per subunit.
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0004252; Molecular function: serine-type endopeptidase activity.
end case

case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
end case


Keywords [?]

case <FTGroup:1>
Hydrolase
Protease
Serine protease
end case

case <FTGroup:2>
Calcium
Metal-binding
end case


Features [?]

From: PS51695
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase S53 #        
ACT_SITE     76     76       Charge relay system     E   1
ACT_SITE     80     80       Charge relay system     D   1
ACT_SITE     290     290       Charge relay system     S   1
BINDING     332     332       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     D   2
BINDING     333     333       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     [IV]   2
BINDING     354     354       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     G   2
BINDING     356     356       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     D   2

Additional information [?]

Size range 343-439 amino acids
Related rules None
Repeats 1
Topology Undefined
Example C5FHK0 (SED1_ARTOC)
Scope
Eukaryota
Bacteria; Pseudomonadota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]