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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01032


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01032
General rule information [?]

Accession PRU01032
Dates 20-AUG-2014 (Created)
26-JAN-2023 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51695; SEDOLISIN
Name Sedolisin domain
Function Sedolisins (serine-carboxyl peptidases) are proteolytic enzymes whose fold ressembles that of subtilisin; however they are considerably larger, with the mature catalytic domains containing approximately 375 amino acids. The defining features of these enzymes are a unique catalytic triad, Ser-Glu-Asp (SED in single-letter notation), as well as the presence of an aspartic acid residue in the oxyanion hole.
Scope(s) Eukaryota
Bacteria
Pseudomonadota
Example(s) C5FHK0;

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
end case

Keywords [?]

case <FTGroup:1>
Hydrolase
Protease
Serine protease
end case
case <FTGroup:2>
Calcium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004252; Molecular function:serine-type endopeptidase activity
end case
case <FTGroup:2>
GO:0046872; Molecular function:metal ion binding
end case

Features [?]

From: PS51695
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S53 #"
ACT_SITE 76 76 /note="Charge relay system" E 1
ACT_SITE 80 80 /note="Charge relay system" D 1
ACT_SITE 290 290 /note="Charge relay system" S 1
BINDING 332 332 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 2
BINDING 333 333 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 [IV] 2
BINDING 354 354 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 G 2
BINDING 356 356 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 2

Additional information [?]

Size range 343-439 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]