PRU01032
General rule information
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Accession | PRU01032 |
Dates | 20-AUG-2014 (Created) 26-JAN-2023 (Last updated, Version 7) |
Data class | Domain |
Predictors | PROSITE; PS51695; SEDOLISIN |
Name | Sedolisin domain |
Function | Sedolisins (serine-carboxyl peptidases) are proteolytic enzymes whose fold ressembles that of subtilisin; however they are considerably larger, with the mature catalytic domains containing approximately 375 amino acids. The defining features of these enzymes are a unique catalytic triad, Ser-Glu-Asp (SED in single-letter notation), as well as the presence of an aspartic acid residue in the oxyanion hole. |
Propagated annotation
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Comments
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case <FTGroup:2>
Cofactor | Ca(2+) Note: Binds 1 Ca(2+) ion per subunit. |
end case
Gene Ontology
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case <FTGroup:1>
GO:0004252; Molecular function: serine-type endopeptidase activity.
end case
case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
end case
Keywords
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case <FTGroup:1>
end case
case <FTGroup:2>
end case
Features
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From: PS51695 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Peptidase S53 # | |||||||||
ACT_SITE | 76 | 76 | Charge relay system | E | 1 | |||||||
ACT_SITE | 80 | 80 | Charge relay system | D | 1 | |||||||
ACT_SITE | 290 | 290 | Charge relay system | S | 1 | |||||||
BINDING | 332 | 332 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108 | D | 2 | |||||||
BINDING | 333 | 333 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108 | [IV] | 2 | |||||||
BINDING | 354 | 354 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108 | G | 2 | |||||||
BINDING | 356 | 356 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108 | D | 2 |
Additional information
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Size range | 343-439 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | C5FHK0 (SED1_ARTOC) |
Scope | Eukaryota
Bacteria; Pseudomonadota |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Bacteria [2] Eukaryota [27] All [ 29 ]
- Retrieve set of proteins with 3D structure for this domain