ProRule PRU01032
General rule information
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| Accession | PRU01032 |
| Dates | 20-AUG-2014 (Created)
26-JAN-2023 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51695; SEDOLISIN |
Name | Sedolisin domain |
| Function | Sedolisins (serine-carboxyl peptidases) are proteolytic enzymes whose fold ressembles that of subtilisin; however they are considerably larger, with the mature catalytic domains containing approximately 375 amino acids. The defining features of these enzymes are a unique catalytic triad, Ser-Glu-Asp (SED in single-letter notation), as well as the presence of an aspartic acid residue in the oxyanion hole. |
| Scope(s) |
Eukaryota Bacteria Pseudomonadota |
| Example(s) | C5FHK0 (SED1_ARTOC); |
Propagated annotation
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Comments
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| case <FTGroup:2> | |
| COFACTOR | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.; |
| end case | |
Keywords
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| case <FTGroup:1> | |
| Hydrolase | |
| Protease | |
| Serine protease | |
| end case | |
| case <FTGroup:2> | |
| Calcium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0004252; Molecular function:serine-type endopeptidase activity | |
| end case | |
| case <FTGroup:2> | |
| GO:0046872; Molecular function:metal ion binding | |
| end case | |
Features
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| From: PS51695 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase S53 #" | |||||||||
| ACT_SITE | 76 | 76 | /note="Charge relay system" | E | 1 | |||||||
| ACT_SITE | 80 | 80 | /note="Charge relay system" | D | 1 | |||||||
| ACT_SITE | 290 | 290 | /note="Charge relay system" | S | 1 | |||||||
| BINDING | 332 | 332 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
D | 2 | |||||||
| BINDING | 333 | 333 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
[IV] | 2 | |||||||
| BINDING | 354 | 354 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
G | 2 | |||||||
| BINDING | 356 | 356 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
D | 2 | |||||||
Additional information
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| Size range | 343-439 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [4] Eukaryota [27] All [ 31 ]
- Retrieve set of proteins with 3D structure for this domain