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General rule information [?]

Accession PRU01042
Dates 20-FEB-2014 (Created)
19-NOV-2022 (Last updated, Version 20)
Data class Domain
Predictors PROSITE; PS51705; G_HFLX
Name HflX-type guanine nucleotide-binding (G) domain
Function The broad phylogenetic distribution pattern of HflX GTPases in Bacteria, Archaea, and Eukaryotes (including human) suggests a basic cellular function for this protein family.

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
Cofactor Mg(2+)
end case

Similarity Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
end case

case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
GO:0000287; Molecular function: magnesium ion binding.
end case

Keywords [?]

case <FTGroup:1>
end case

case <FTGroup:2>
end case

Features [?]

From: PS51705
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Hflx-type G #        
BINDING     7     14       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     G-x(4)-G-K-[ST]   1
BINDING     32     36       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     x(2)-[TS]-x(2)   1
BINDING     54     57       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-x(2)-G   1
BINDING     120     123       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     [NT]-K-x-D   1
BINDING     145     147       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565         1
BINDING     14     14       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [ST]   2
BINDING     34     34       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [ST]   2

Additional information [?]

Size range 151-250 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q980M3 (HFLX_SACS2)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]