PRU01042
General rule information
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Accession | PRU01042 |
Dates | 20-FEB-2014 (Created) 19-NOV-2022 (Last updated, Version 20) |
Data class | Domain |
Predictors | PROSITE; PS51705; G_HFLX |
Name | HflX-type guanine nucleotide-binding (G) domain |
Function | The broad phylogenetic distribution pattern of HflX GTPases in Bacteria, Archaea, and Eukaryotes (including human) suggests a basic cellular function for this protein family. |
Propagated annotation
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Comments
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case <FTGroup:2>
Cofactor | Mg(2+) |
end case
Similarity | Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. |
Gene Ontology
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case <FTGroup:1>
end case
case <FTGroup:2>
GO:0046872; Molecular function: metal ion binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0000287; Molecular function: magnesium ion binding.
end case
Keywords
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case <FTGroup:1>
end case
case <FTGroup:2>
end case
Features
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From: PS51705 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Hflx-type G # | |||||||||
BINDING | 7 | 14 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | G-x(4)-G-K-[ST] | 1 | |||||||
BINDING | 32 | 36 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | x(2)-[TS]-x(2) | 1 | |||||||
BINDING | 54 | 57 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | D-x(2)-G | 1 | |||||||
BINDING | 120 | 123 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | [NT]-K-x-D | 1 | |||||||
BINDING | 145 | 147 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565 | 1 | ||||||||
BINDING | 14 | 14 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | [ST] | 2 | |||||||
BINDING | 34 | 34 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | [ST] | 2 |
Additional information
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Size range | 151-250 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q980M3 (HFLX_SACS2) |
Scope | Bacteria
Archaea
Eukaryota |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Archaea [6] Bacteria [16] Eukaryota [4] All [ 26 ]
- Retrieve set of proteins with 3D structure for this domain