PRU01042

Accession	PRU01042
Dates	20-FEB-2014 (Created) 19-NOV-2022 (Last updated, Version 20)

Data class

Domain

Predictors

PROSITE; PS51705; G_HFLX

Name	HflX-type guanine nucleotide-binding (G) domain

Function

The broad phylogenetic distribution pattern of HflX GTPases in Bacteria, Archaea, and Eukaryotes (including human) suggests a basic cellular function for this protein family.

Cofactor

Mg(2+)

Similarity

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.

GO:0046872; Molecular function: metal ion binding.
GO:0000287; Molecular function: magnesium ion binding.

GTP-binding
Nucleotide-binding

Magnesium
Metal-binding

From: PS51705

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

Hflx-type G #

BINDING

7

14

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565

G-x(4)-G-K-[ST]

1

BINDING

32

36

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565

x(2)-[TS]-x(2)

1

BINDING

54

57

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565

D-x(2)-G

1

BINDING

120

123

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565

[NT]-K-x-D

1

BINDING

145

147

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565

1

BINDING

14

14

/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420

[ST]

2

BINDING

34

34

/ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420

[ST]

2

Size range	151-250 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q980M3 (HFLX_SACS2)
Scope	Bacteria Archaea Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

• UniProtKB/Swiss-Prot sets
  

  Archaea	[6]
  Bacteria	[16]
  Eukaryota	[4]
  All	[ 26 ]

  
  
• Retrieve set of proteins with 3D structure for this domain