We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ProRule PRU01042

View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01042

General rule information [?]

Accession	PRU01042
Dates	20-FEB-2014 (Created) 19-NOV-2022 (Last updated, Version 21)
Data class	Domain;
Predictors	PROSITE; PS51705; G_HFLX
Name	HflX-type guanine nucleotide-binding (G) domain
Function	The broad phylogenetic distribution pattern of HflX GTPases in Bacteria, Archaea, and Eukaryotes (including human) suggests a basic cellular function for this protein family.
Scope(s)	Bacteria Archaea Eukaryota
Example(s)	Q980M3;

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITY	Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.

Keywords [?]

case <FTGroup:1>
GTP-binding
Nucleotide-binding
end case
case <FTGroup:2>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
end case
case <FTGroup:2>
GO:0046872; Molecular function:metal ion binding
GO:0000287; Molecular function:magnesium ion binding
end case

Features [?]

From: PS51705

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="Hflx-type G #"

BINDING