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ProRule PRU01042


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01042
Accession PRU01042
Dates 20-FEB-2014 (Created)
19-NOV-2022 (Last updated, Version 20)
Data class Domain;
Predictors PROSITE; PS51705; G_HFLX
Name HflX-type guanine nucleotide-binding (G) domain
Function The broad phylogenetic distribution pattern of HflX GTPases in Bacteria, Archaea, and Eukaryotes (including human) suggests a basic cellular function for this protein family.
Scope(s) Bacteria
Archaea
Eukaryota
Example(s) Q980M3 (HFLX_SACS2);

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITYBelongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.

Keywords [?]

case <FTGroup:1>
GTP-binding
Nucleotide-binding
end case
case <FTGroup:2>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
end case
case <FTGroup:2>
GO:0046872; Molecular function:metal ion binding
GO:0000287; Molecular function:magnesium ion binding
end case

Features [?]

From: PS51705
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Hflx-type G #"
BINDING 7 14 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 G-x(4)-G-K-[ST] 1
BINDING 32 36 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 x(2)-[TS]-x(2) 1
BINDING 54 57 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 D-x(2)-G 1
BINDING 120 123 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 [NT]-K-x-D 1
BINDING 145 147 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 1
BINDING 14 14 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2
BINDING 34 34 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 2

Additional information [?]

Size range 151-250 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]