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annotation rule: PRU01043

General rule information [?]

Accession PRU01043
Dates 25-MAR-2014 (Created)
19-NOV-2022 (Last updated, Version 14)
Data class Domain
Predictors PROSITE; PS51706; G_ENGB
Name EngB-type guanine nucleotide-binding (G) domain
Function Proteins of the EngB-type GTPase family are involved in the biogenesis of ribosomes and are essential for the survival of a wide range of bacteria.

Propagated annotation [?]


Comments [?]

case <FTGroup:2>
Cofactor Mg(2+)
end case

Similarity Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
end case

case <FTGroup:2>
GO:0000287; Molecular function: magnesium ion binding.
GO:0046872; Molecular function: metal ion binding.
end case


Keywords [?]

case <FTGroup:1>
GTP-binding
Nucleotide-binding
end case

case <FTGroup:2>
Magnesium
Metal-binding
end case


Features [?]

From: PS51706
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       EngB-type G #        
BINDING     9     16       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     G-x(4)-G-K-[ST]   1
BINDING     36     40       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     x(2)-[ST]-x(2)   1
BINDING     55     58       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-x(2)-G   1
BINDING     122     125       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     [NT]-K-x-D   1
BINDING     157     159       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565         1
BINDING     16     16       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [ST]   2
BINDING     38     38       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     [ST]   2

Additional information [?]

Size range 153-218 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P38424 (ENGB_BACSU)
Scope
Bacteria
Archaea; Euryarchaeota
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]