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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01047


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01047
General rule information [?]

Accession PRU01047
Dates 14-MAR-2014 (Created)
08-OCT-2024 (Last updated, Version 22)
Data class Domain;
Predictors PROSITE; PS51710; G_OBG
Name OBG-type guanine nucleotide-binding (G) domain
Function Within the translation factor-related (TRAFAC) class of P-loop GTPases, the OBG family comprises a group of high-molecular mass GTPases conserved from bacteria to eukaryotes.
Scope(s) Bacteria
Eukaryota
Archaea
Methanobacteriati
Example(s) Q72HR4; Q9NTK5;

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITYBelongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

Keywords [?]

case <FTGroup:1>
GTP-binding
end case
case <FTGroup:2>
ATP-binding
end case
case <FTGroup:1> and <FTGroup:2>
Nucleotide-binding
end case
case <FTGroup:3>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity
end case
case <FTGroup:2>
GO:0005524; Molecular function:ATP binding
GO:0016887; Molecular function:ATP hydrolysis activity
end case
case <FTGroup:3>
GO:0046872; Molecular function:metal ion binding
GO:0000287; Molecular function:magnesium ion binding
end case

Features [?]

From: PS51710
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="OBG-type G #"
BINDING 7 14 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 G-x(4)-G-K-[ST] 1
BINDING 32 36 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 x(2)-[ST]-x(2) 1
BINDING 54 57 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 D-x(2)-G 1
BINDING 126 129 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 [NT]-K-x-D 1
BINDING 156 158 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"		 1
BINDING 7 14 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 G-x(4)-G-K-[ST] 2
BINDING 32 36 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 x(2)-[ST]-x(2) 2
BINDING 54 57 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 D-x(2)-G 2
BINDING 126 129 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 N-x(2)-[EQ] 2
BINDING 156 158 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 2
BINDING 14 14 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 3
BINDING 34 34 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 [ST] 3

Additional information [?]

Size range 51-280 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]