PRU01049

Accession	PRU01049
Dates	1-APR-2014 (Created) 19-NOV-2022 (Last updated, Version 10)

Data class

Domain

Predictors

PROSITE; PS51712; G_ENGA

Name	EngA-type guanine nucleotide-binding (G) domain

Function

EngA (Essential neisserial GTPase A) proteins belong to TrmE-Era- EngA-YihA-Septin like superfamily of TRAFAC class and form a unique family of bacterial GTPases with two G domains in tandem, namely GD1 and GD2, followed by a C-terminal KH-like domain. They have been shown to interact with the bacterial ribosome and to be involved in its biogenesis.

Similarity

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.

GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.

GTP-binding
Nucleotide-binding

From: PS51712

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

EngA-type G #

BINDING

7

14

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" /ligand_label="#1

G-x(4)-G-K-[ST]

1

BINDING

33

37

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" /ligand_label="#1

x(2)-[ST]-x(2)

1

BINDING

54

57

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" /ligand_label="#1

D-x(2)-G

1

BINDING

119

122

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" /ligand_label="#1

N-K-x-[DE]

1

BINDING

149

151

/ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" /ligand_label="#1

1

Size range	152-194 amino acids
Related rules	None
Repeats	2
Topology	Undefined
Example	P50743 (DER_BACSU)
Scope	Bacteria
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Bacteria

  [622]

  
  
• Retrieve set of proteins with 3D structure for this domain