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ProRule PRU01049


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PURL: https://purl.expasy.org/prosite/rule/PRU01049
General rule information [?]

Accession PRU01049
Dates 1-APR-2014 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51712; G_ENGA
Name EngA-type guanine nucleotide-binding (G) domain
Function EngA (Essential neisserial GTPase A) proteins belong to TrmE-Era- EngA-YihA-Septin like superfamily of TRAFAC class and form a unique family of bacterial GTPases with two G domains in tandem, namely GD1 and GD2, followed by a C-terminal KH-like domain. They have been shown to interact with the bacterial ribosome and to be involved in its biogenesis.
Scope(s) Bacteria
Example(s) P50743 (DER_BACSU);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.

Keywords [?]

GTP-binding
Nucleotide-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity

Features [?]

From: PS51712
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="EngA-type G #"
BINDING 7 14 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#1"		 G-x(4)-G-K-[ST] 1
BINDING 33 37 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#1"		 x(2)-[ST]-x(2) 1
BINDING 54 57 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#1"		 D-x(2)-G 1
BINDING 119 122 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#1"		 N-K-x-[DE] 1
BINDING 149 151 /ligand="GTP"
/ligand_id="ChEBI:CHEBI:37565"
/ligand_label="#1"		 1

Additional information [?]

Size range 152-194 amino acids
Related rules None
Fusion None
Repeats 2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]