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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01052


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01052
General rule information [?]

Accession PRU01052
Dates 11-MAY-2020 (Created)
13-MAY-2020 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51715; G_GB1_RHD3
Name GB1/RHD3-type guanine nucleotide-binding (G) domain
Function The GB1/RHD3 GTPase family contains a large G domain (~230 amino acids). The GB1/RHD3-type G domain has a low intrinsic affinity for nucleotide and often depends on nucleotide-dependent homodimerization to facilitate GTP hydrolysis.
Scope(s) Eukaryota
Example(s) Q8NHH9;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

Keywords [?]

GTP-binding
Hydrolase
Nucleotide-binding
end case

Gene Ontology [?]

case <Feature:PS51715:11-18=G-x(4)-G-K-[ST]> and <Feature:PS51715:67=D> and <Feature:PS51715:138-141=[ILV]-V-R-D>
GO:0005525; Molecular function:GTP binding

Features [?]

From: PS51715
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GB1/RHD3-type G #"

Additional information [?]

Size range 205-282 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]