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ProRule PRU01058


General rule information [?]

Accession PRU01058
Dates 20-JUN-2014 (Created)
8-OCT-2024 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51721; G_CP
Name Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
Function The TRAFAC (named after translation factors) class includes an atypical family characterized by a circularly permuted (CP) order of the GTPase motifs within the G domain: the normal G1-G2-G3-G4-G5 orientation of the G domain has been rearranged to G4(N/T-K-x-D)-G5(T/G-C/S-A)-G1(Walker A, P-loop)-G2(T)-G3(Walker B).
Scope(s) Bacteria
Eukaryota
Archaea
Methanobacteriati
Example(s) Q9H089 (LSG1_HUMAN);

Propagated annotation [?]

Comments [?]

case <Feature:PS50936>
SIMILARITYBelongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
else
SIMILARITYBelongs to the TRAFAC class YlqF/YawG GTPase family.
end case

Keywords [?]

GTP-binding
Nucleotide-binding
Hydrolase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity

Features [?]

From: PS51721
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CP-type G #"
REGION 46 49 /note="G4 #" [NST]-K-x-D 1
REGION 76 78 /note="G5 #" 1
REGION 100 107 /note="G1 #" G-x(4)-G-K-[ST] 1
REGION 132 136 /note="G2 #" x(2)-[TS]-x(2) 1
REGION 150 153 /note="G3 #" D-x(2)-G 1

Additional information [?]

Size range 142-313 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]