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annotation rule: PRU01058

General rule information [?]

Accession PRU01058
Dates 20-JUN-2014 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51721; G_CP
Name Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
Function The TRAFAC (named after translation factors) class includes an atypical family characterized by a circularly permuted (CP) order of the GTPase motifs within the G domain: the normal G1-G2-G3-G4-G5 orientation of the G domain has been rearranged to G4(N/T-K-x-D)-G5(T/G-C/S-A)-G1(Walker A, P-loop)-G2(T)-G3(Walker B).

Propagated annotation [?]


Comments [?]

case <Feature:PS50936>
Similarity Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
else
Similarity Belongs to the TRAFAC class YlqF/YawG GTPase family.
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.

Keywords [?]

GTP-binding
Nucleotide-binding
Hydrolase
end case


Features [?]

From: PS51721
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CP-type G #        
REGION     46     49       G4 #     [NST]-K-x-D   1
REGION     76     78       G5 #         1
REGION     100     107       G1 #     G-x(4)-G-K-[ST]   1
REGION     132     136       G2 #     x(2)-[TS]-x(2)   1
REGION     150     153       G3 #     D-x(2)-G   1

Additional information [?]

Size range 142-313 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9H089 (LSG1_HUMAN)
Scope
Bacteria
Eukaryota
Archaea; Euryarchaeota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]