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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01058


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01058
General rule information [?]

Accession PRU01058
Dates 20-JUN-2014 (Created)
08-OCT-2024 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51721; G_CP
Name Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
Function The TRAFAC (named after translation factors) class includes an atypical family characterized by a circularly permuted (CP) order of the GTPase motifs within the G domain: the normal G1-G2-G3-G4-G5 orientation of the G domain has been rearranged to G4(N/T-K-x-D)-G5(T/G-C/S-A)-G1(Walker A, P-loop)-G2(T)-G3(Walker B).
Scope(s) Bacteria
Eukaryota
Archaea
Methanobacteriati
Example(s) Q9H089;

Propagated annotation [?]

Comments [?]

case <Feature:PS50936>
SIMILARITYBelongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
else
SIMILARITYBelongs to the TRAFAC class YlqF/YawG GTPase family.
end case

Keywords [?]

GTP-binding
Nucleotide-binding
Hydrolase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005525; Molecular function:GTP binding
GO:0003924; Molecular function:GTPase activity

Features [?]

From: PS51721
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CP-type G #"
REGION 46 49 /note="G4 #" [NST]-K-x-D 1
REGION 76 78 /note="G5 #" 1
REGION 100 107 /note="G1 #" G-x(4)-G-K-[ST] 1
REGION 132 136 /note="G2 #" x(2)-[TS]-x(2) 1
REGION 150 153 /note="G3 #" D-x(2)-G 1

Additional information [?]

Size range 142-313 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]