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annotation rule: PRU01063

General rule information [?]

Accession PRU01063
Dates 14-JUN-2016 (Created)
27-OCT-2018 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51726; MYST_HAT
Name MYST-type histone acetyltransferase (HAT) domain
Function The MYST-type HAT domain contains three regions: a central region associated with acetyl-CoA cofactor binding and catalysis in addition to flanking N- and C-terminal regions harboring respectively a C2HC-type zinc finger and a helix-turn-helix DNA-binding motif.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC=2.3.1.48;

Comments [?]

Catalytic activity Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)- acetyl-L-lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;.
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0004402; Molecular function: histone acetyltransferase activity.
end case

case <FT:2> or <FT:3>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

case <FTGroup:1>
end case


Features [?]

From: PS51726
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MYST-type HAT #        
case <Feature:PS51726:37=[C]> and <Feature:PS51726:40=[C]> and <Feature:PS51726:53=[H]> and <Feature:PS51726:57=[C]>
ZN_FING     34     59       C2HC MYST-type #        
else case <Feature:PS51726:37=[CH]> and <Feature:PS51726:40=[CH]> and <Feature:PS51726:53=[CH]> and <Feature:PS51726:57=[CH]>
ZN_FING     34     59       C2HC MYST-type #; atypical        
else
ZN_FING     34     59       C2HC MYST-type #; degenerate        
end case

case <Feature:PS51726:151-157=[MQ]-[KR]-[AHKLMQR]-G-[FLY]-G-[KLQRSV]>
REGION     151     157       Acetyl-CoA binding         1
end case

case <Feature:PS51726:142-146=[AS]-C-I-[LM]-[TIV]>
REGION     142     146       Acetyl-CoA binding         1
end case

ACT_SITE     177     177       Proton donor/acceptor     E   1
BINDING     181     181       Acetyl-CoA     S   1
case <FTGroup:1>
BINDING     190     190       Acetyl-CoA     S  
BINDING     260     260       Acetyl-CoA     K  
end case

MOD_RES     101     101       N6-acetyllysine; by autocatalysis     K   1

Additional information [?]

Size range 260-344 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9LXD7 (MYST2_ARATH)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]