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ProRule PRU01063


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PURL: https://purl.expasy.org/prosite/rule/PRU01063
General rule information [?]

Accession PRU01063
Dates 14-JUN-2016 (Created)
03-SEP-2024 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51726; MYST_HAT
Name MYST-type histone acetyltransferase (HAT) domain
Function The MYST-type HAT domain contains three regions: a central region associated with acetyl-CoA cofactor binding and catalysis in addition to flanking N- and C-terminal regions harboring respectively a C2HC-type zinc finger and a helix-turn-helix DNA-binding motif.
Scope(s) Eukaryota
Example(s) Q9LXD7;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=2.3.1.48;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+); Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
end case

Keywords [?]

Zinc
Metal-binding
end case
case <FTGroup:1>
Zinc-finger
Acetylation
Transferase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004402; Molecular function:histone acetyltransferase activity
end case
case <FT:2> or <FT:3>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51726
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MYST-type HAT #"
case <Feature:PS51726:37=[C]> and <Feature:PS51726:40=[C]> and <Feature:PS51726:53=[H]> and <Feature:PS51726:57=[C]>
ZN_FING 34 59 /note="C2HC MYST-type #"
else case <Feature:PS51726:37=[CH]> and <Feature:PS51726:40=[CH]> and <Feature:PS51726:53=[CH]> and <Feature:PS51726:57=[CH]>
ZN_FING 34 59 /note="C2HC MYST-type #; atypical"
else
ZN_FING 34 59 /note="C2HC MYST-type #; degenerate"
end case
case <Feature:PS51726:151-157=[MQ]-[KR]-[AHKLMQR]-G-[FLY]-G-[KLQRSV]>
BINDING 151 157 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 1
end case
case <Feature:PS51726:142-146=[AS]-C-I-[LM]-[TIV]>
BINDING 142 146 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 1
end case
ACT_SITE 177 177 /note="Proton donor/acceptor" E 1
BINDING 181 181 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 S 1
case <FTGroup:1>
BINDING 190 190 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 S
BINDING 260 260 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 K
end case
MOD_RES 101 101 /note="N6-acetyllysine; by autocatalysis" K 1

Additional information [?]

Size range 260-344 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]