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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01063


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01063
General rule information [?]

Accession PRU01063
Dates 14-JUN-2016 (Created)
03-SEP-2024 (Last updated, Version 14)
Data class Domain;
Predictors PROSITE; PS51726; MYST_HAT
Name MYST-type histone acetyltransferase (HAT) domain
Function The MYST-type HAT domain contains three regions: a central region associated with acetyl-CoA cofactor binding and catalysis in addition to flanking N- and C-terminal regions harboring respectively a C2HC-type zinc finger and a helix-turn-helix DNA-binding motif.
Scope(s) Eukaryota
Example(s) Q9LXD7;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=2.3.1.48;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+); Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
end case

Keywords [?]

Zinc
Metal-binding
end case
case <FTGroup:1>
Zinc-finger
Acetylation
Transferase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004402; Molecular function:histone acetyltransferase activity
end case
case <FT:2> or <FT:3>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51726
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MYST-type HAT #"
case <Feature:PS51726:37=[C]> and <Feature:PS51726:40=[C]> and <Feature:PS51726:53=[H]> and <Feature:PS51726:57=[C]>
ZN_FING 34 59 /note="C2HC MYST-type #"
else case <Feature:PS51726:37=[CH]> and <Feature:PS51726:40=[CH]> and <Feature:PS51726:53=[CH]> and <Feature:PS51726:57=[CH]>
ZN_FING 34 59 /note="C2HC MYST-type #; atypical"
else
ZN_FING 34 59 /note="C2HC MYST-type #; degenerate"
end case
case <Feature:PS51726:151-157=[MQ]-[KR]-[AHKLMQR]-G-[FLY]-G-[KLQRSV]>
BINDING 151 157 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 1
end case
case <Feature:PS51726:142-146=[AS]-C-I-[LM]-[TIV]>
BINDING 142 146 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 1
end case
ACT_SITE 177 177 /note="Proton donor/acceptor" E 1
BINDING 181 181 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 S 1
case <FTGroup:1>
BINDING 190 190 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 S
BINDING 260 260 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 K
end case
MOD_RES 101 101 /note="N6-acetyllysine; by autocatalysis" K 1

Additional information [?]

Size range 260-344 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]