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annotation rule: PRU01065

General rule information [?]

Accession PRU01065
Dates 26-AUG-2014 (Created)
19-DEC-2016 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51727; CBP_P300_HAT
Name CBP/p300-type histone acetyltransferase (HAT) domain profile
Function CREB-binding protein (CBP)/p300 proteins are involved in various physiological events including proliferation, differentiation and apoptosis. CBP/p300 proteins contain several well-defined protein-interaction domains as well as a centrally located 380-residue HAT domain.

Propagated annotation [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0004402; Molecular function: histone acetyltransferase activity.

Keywords [?]

end case


Features [?]

From: PS51727
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       CBP/p300-type HAT #        
REGION     114     116       Acetyl-CoA binding     [IL]-D-S   1
REGION     126     127       Acetyl-CoA binding     R-T   1
BINDING     173     173       Acetyl-CoA; via carbonyl oxygen     [I]   1
BINDING     178     178       Acetyl-CoA     [R]   1
BINDING     182     182       Acetyl-CoA     W   1

Additional information [?]

Size range 367-448 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9LG11 (HAC4_ARATH)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]