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ProRule PRU01065


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PURL: https://purl.expasy.org/prosite/rule/PRU01065
General rule information [?]

Accession PRU01065
Dates 26-AUG-2014 (Created)
19-NOV-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51727; CBP_P300_HAT
Name CBP/p300-type histone acetyltransferase (HAT) domain profile
Function CREB-binding protein (CBP)/p300 proteins are involved in various physiological events including proliferation, differentiation and apoptosis. CBP/p300 proteins contain several well-defined protein-interaction domains as well as a centrally located 380-residue HAT domain.
Scope(s) Eukaryota
Example(s) Q9LG11;

Propagated annotation [?]

Keywords [?]

Acyltransferase
Transferase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004402; Molecular function:histone acetyltransferase activity

Features [?]

From: PS51727
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CBP/p300-type HAT #"
BINDING 114 116 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 [IL]-D-S 1
BINDING 126 127 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 R-T 1
BINDING 173 173 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 [I] 1
BINDING 178 178 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 [R] 1
BINDING 182 182 /ligand="acetyl-CoA"
/ligand_id="ChEBI:CHEBI:57288"		 W 1

Additional information [?]

Size range 367-448 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]