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ProRule PRU01066


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01066
Accession PRU01066
Dates 24-SEP-2014 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS50968; BIOTINYL_LIPOYL
Name Biotinyl/lipoyl domain
Function Biotin and lipoic acid moieties are the covalently bound cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. They are attached to a lysine residue, via an amide bond, by specific biotinyl and lipoyl protein ligases.
Scope(s) Bacteria
Eukaryota
Archaea
Example(s) P0A6T9 (GCSH_ECOLI); P0ABD8 (BCCP_ECOLI);

Propagated annotation [?]

Comments [?]

case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
COFACTOR Name=biotin; Xref=ChEBI:CHEBI:57586;
else case <Feature:PS50968:42=K>
COFACTOR Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
end case

Keywords [?]

case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
Biotin
else case <Feature:PS50968:42=K>
Lipoyl
end case

Features [?]

From: PS50968
Key From To Description Tag Condition FTGroup
case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
DOMAIN from to /note="Biotinyl-binding #"
MOD_RES 42 42 /note="N6-biotinyllysine" K
else
DOMAIN from to /note="Lipoyl-binding #"
MOD_RES 42 42 /note="N6-lipoyllysine" K
end case

Additional information [?]

Size range 57-96 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]