PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01066


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01066
General rule information [?]

Accession PRU01066
Dates 24-SEP-2014 (Created)
22-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS50968; BIOTINYL_LIPOYL
Name Biotinyl/lipoyl domain
Function Biotin and lipoic acid moieties are the covalently bound cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. They are attached to a lysine residue, via an amide bond, by specific biotinyl and lipoyl protein ligases.
Scope(s) Bacteria
Eukaryota
Archaea
Example(s) P0A6T9; P0ABD8;

Propagated annotation [?]

Comments [?]

case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
COFACTOR Name=biotin; Xref=ChEBI:CHEBI:57586;
else case <Feature:PS50968:42=K>
COFACTOR Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
end case

Keywords [?]

case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
Biotin
else case <Feature:PS50968:42=K>
Lipoyl
end case

Features [?]

From: PS50968
Key From To Description Tag Condition FTGroup
case <Feature:PS50968:41-42=M-K> or <Feature:PS50968:42-43=K-M>
DOMAIN from to /note="Biotinyl-binding #"
MOD_RES 42 42 /note="N6-biotinyllysine" K
else
DOMAIN from to /note="Lipoyl-binding #"
MOD_RES 42 42 /note="N6-lipoyllysine" K
end case

Additional information [?]

Size range 57-96 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]