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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01074


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01074
General rule information [?]

Accession PRU01074
Dates 27-NOV-2014 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51738; PEPTIDASE_C21
Name Peptidase family C21 domain
Function The peptidase family C21 domain is a papain-like proteinase with catalytic cysteine and histidine residues.
Scope(s) Viruses
Tymoviridae
Example(s) P28477;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004197; Molecular function:cysteine-type endopeptidase activity
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity

Features [?]

From: PS51738
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C21 #"
ACT_SITE 54 54 /note="For protease activity" C 1
ACT_SITE 140 140 /note="For protease activity" H 1

Additional information [?]

Size range 140-166 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]