ProRule PRU01084
General rule information
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| Accession | PRU01084 |
| Dates | 18-FEB-2015 (Created)
5-FEB-2024 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51748; HEXOKINASE_2 |
Name | Hexokinase domain |
| Function | Hexokinase (EC 2.7.1.1) [1,2] is an important glycolytic enzyme that catalyzes the phosphorylation of keto- and aldohexoses (e.g. glucose, mannose and fructose) using MgATP as the phosphoryl donor. |
| Scope(s) |
Eukaryota |
| Example(s) | P27881 (HXK2_RAT); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.7.1.1; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:229467, ChEBI:CHEBI:456216; EC=2.7.1.1; |
| SIMILARITY | Belongs to the hexokinase family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0006096; Biological process:glycolytic process |
Cross-references
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| PROSITE | PS00378; HEXOKINASE_1; 1-2; |
Features
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| From: PS51748 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Hexokinase #" | |||||||||
| REGION | 56 | 191 | /note="Hexokinase small subdomain #" | |||||||||
| REGION | 192 | 435 | /note="Hexokinase large subdomain #" | |||||||||
Additional information
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| Size range | 414-497 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [62] All [ 62 ]
- Retrieve set of proteins with 3D structure for this domain