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annotation rule: PRU01084

General rule information [?]

Accession PRU01084
Dates 18-FEB-2015 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51748; HEXOKINASE_2
Name Hexokinase domain
Function Hexokinase (EC 2.7.1.1) [1,2] is an important glycolytic enzyme that catalyzes the phosphorylation of keto- and aldohexoses (e.g. glucose, mannose and fructose) using MgATP as the phosphoryl donor.

Propagated annotation [?]


Description [?]

+ RecName: EC 2.7.1.-;

Comments [?]

Catalytic activity RHEA:22740: ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+)
Similarity Belongs to the hexokinase family.

Cross-references [?]

PROSITE PS00378; HEXOKINASE_1; 1-2;

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0006096; Biological process: glycolytic process.

Keywords [?]

ATP-binding
Glycolysis
Kinase
Nucleotide-binding
Transferase

Features [?]

From: PS51748
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Hexokinase #        
REGION     56     191       Hexokinase small subdomain #        
REGION     192     435       Hexokinase large subdomain #        

Additional information [?]

Size range 414-497 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example P27881 (HXK2_RAT)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]