We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01084
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01084
General rule information
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| Accession | PRU01084 |
| Dates | 18-FEB-2015 (Created)
05-FEB-2024 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51748; HEXOKINASE_2 |
Name | Hexokinase domain |
| Function | Hexokinase (EC 2.7.1.1) [1,2] is an important glycolytic enzyme that catalyzes the phosphorylation of keto- and aldohexoses (e.g. glucose, mannose and fructose) using MgATP as the phosphoryl donor. |
| Scope(s) |
Eukaryota |
| Example(s) | P27881; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=2.7.1.1; |
Comments
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| CATALYTIC ACTIVITY | Reaction=a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:229467, ChEBI:CHEBI:456216; EC=2.7.1.1; |
| SIMILARITY | Belongs to the hexokinase family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0006096; Biological process:glycolytic process |
Cross-references
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| PROSITE | PS00378; HEXOKINASE_1; 1-2; |
Features
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| From: PS51748 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Hexokinase #" | |||||||||
| REGION | 56 | 191 | /note="Hexokinase small subdomain #" | |||||||||
| REGION | 192 | 435 | /note="Hexokinase large subdomain #" | |||||||||
Additional information
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| Size range | 414-497 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [62] All [ 62 ]
- Retrieve set of proteins with 3D structure for this domain