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annotation rule: PRU01084

General rule information [?]

Accession PRU01084
Dates 18-FEB-2015 (Created)
27-OCT-2018 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51748; HEXOKINASE_2
Name Hexokinase domain
Function Hexokinase (EC [1,2] is an important glycolytic enzyme that catalyzes the phosphorylation of keto- and aldohexoses (e.g. glucose, mannose and fructose) using MgATP as the phosphoryl donor.

Propagated annotation [?]

Description [?]

+ RecName: EC=2.7.1.-;

Comments [?]

Catalytic activity Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216;.
Similarity Belongs to the hexokinase family.

Cross-references [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0006096; Biological process: glycolytic process.

Keywords [?]

Features [?]

From: PS51748
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Hexokinase #        
REGION     56     191       Hexokinase small subdomain #        
REGION     192     435       Hexokinase large subdomain #        

Additional information [?]

Size range 414-497 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example P27881 (HXK2_RAT)
Comments None


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UniProtKB rule member sequences [?]