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ProRule PRU01084


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01084
Accession PRU01084
Dates 18-FEB-2015 (Created)
5-FEB-2024 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51748; HEXOKINASE_2
Name Hexokinase domain
Function Hexokinase (EC 2.7.1.1) [1,2] is an important glycolytic enzyme that catalyzes the phosphorylation of keto- and aldohexoses (e.g. glucose, mannose and fructose) using MgATP as the phosphoryl donor.
Scope(s) Eukaryota
Example(s) P27881 (HXK2_RAT);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.7.1.1;

Comments [?]

CATALYTIC ACTIVITY Reaction=a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+); Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:229467, ChEBI:CHEBI:456216; EC=2.7.1.1;
SIMILARITYBelongs to the hexokinase family.

Keywords [?]

ATP-binding
Glycolysis
Kinase
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0006096; Biological process:glycolytic process

Cross-references [?]

PROSITE PS00378; HEXOKINASE_1; 1-2;

Features [?]

From: PS51748
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Hexokinase #"
REGION 56 191 /note="Hexokinase small subdomain #"
REGION 192 435 /note="Hexokinase large subdomain #"

Additional information [?]

Size range 414-497 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]