ProRule PRU01085

General rule information [?]

Accession PRU01085
Dates 11-MAR-2015 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51749; HNH_CAS9
Name Cas9-type HNH domain
Function All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand).
Scope(s) Bacteria
Example(s) Q03JI6 (CAS9B_STRTD);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0003723; Molecular function:RNA binding
GO:0004519; Molecular function:endonuclease activity

Features [?]

From: PS51749
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HNH Cas9-type #"

Additional information [?]

Size range 139-182 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]