ProRule logo

General rule information [?]

Accession PRU01085
Dates 11-MAR-2015 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51749; HNH_CAS9
Name Cas9-type HNH domain
Function All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand).

Propagated annotation [?]

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0003723; Molecular function: RNA binding.
GO:0004519; Molecular function: endonuclease activity.

Keywords [?]

Features [?]

From: PS51749
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HNH Cas9-type #        

Additional information [?]

Size range 139-182 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q03JI6 (CAS9B_STRTD)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]