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| annotation rule: PRU01085 |
General rule information
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| Accession | PRU01085 |
| Dates | 11-MAR-2015 (Created) 22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain |
| Predictors | PROSITE; PS51749; HNH_CAS9 |
| Name | Cas9-type HNH domain |
| Function | All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand). |
Propagated annotation
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Gene Ontology
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GO:0003677; Molecular function: DNA binding.
GO:0003723; Molecular function: RNA binding.
GO:0004519; Molecular function: endonuclease activity.
GO:0003723; Molecular function: RNA binding.
GO:0004519; Molecular function: endonuclease activity.
Keywords
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Features
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| From: PS51749 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | HNH Cas9-type # | |||||||||
Additional information
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| Size range | 139-182 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q03JI6 (CAS9B_STRTD) |
| Scope | Bacteria |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Bacteria [14]
- Retrieve set of proteins with 3D structure for this domain