ProRule PRU01085
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01085 |
| Accession | PRU01085 |
| Dates | 11-MAR-2015 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51749; HNH_CAS9 |
Name | Cas9-type HNH domain |
| Function | All known Cas9 enzymes contain an HNH domain that cleaves the DNA strand complementary to the guide RNA sequence (target strand). |
| Scope(s) |
Bacteria |
| Example(s) | Q03JI6 (CAS9B_STRTD); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0003723; Molecular function:RNA binding |
| GO:0004519; Molecular function:endonuclease activity |
Features
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| From: PS51749 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="HNH Cas9-type #" | |||||||||
Additional information
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| Size range | 139-182 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [14] All [ 14 ]
- Retrieve set of proteins with 3D structure for this domain