We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01096
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01096
General rule information
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| Accession | PRU01096 |
| Dates | 15-JUN-2015 (Created)
22-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51760; GH10_2 |
Name | Glycosyl hydrolases family 10 (GH10) domain |
| Function | All family 10 xylanases hydrolyze the glycosidic bond in a double- displacement 'retaining' mechanism using two catalytic acidic residues, where one residue acts a nucleophile (base) and the other acts as a general acid/base. |
| Scope(s) |
Eukaryota Fungi Bacteria |
| Example(s) | O60206; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.2.1.8; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.; EC=3.2.1.8; |
| PATHWAY | Glycan degradation; xylan degradation. |
| end case | |
| SIMILARITY | Belongs to the glycosyl hydrolase 10 (cellulase F) family. |
Keywords
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Gene Ontology
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| GO:0045493; Biological process:xylan catabolic process |
| GO:0031176; Molecular function:endo-1,4-beta-xylanase activity |
Cross-references
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| PROSITE | PS00591; GH10_1; 1; |
Features
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| From: PS51760 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GH10 #" | |||||||||
| ACT_SITE | 137 | 137 | /note="Proton donor" | E | 1 | |||||||
| ACT_SITE | 242 | 242 | /note="Nucleophile" | E | 1 | |||||||
Additional information
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| Size range | 260-375 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [32] Eukaryota [55] All [ 87 ]
- Retrieve set of proteins with 3D structure for this domain