ProRule PRU01107

General rule information [?]

Accession PRU01107
Dates 21-AUG-2015 (Created)
3-JUN-2021 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51771; CGT_MARTX_CPD
Name CGT/MARTX cysteine protease (CPD) domain
Function The clostridial glucosylating toxins (CGTs) produced by Gram- positive bacteria and the multifunctional-autoprocessing RTX (MARTX) toxins of Gram-negative bacteria carry an embedded cysteine protease domain (CPD) that is regulated by a unique allosteric activation mechanism. The CGT/MARTX CPD catalytic dyad is composed of one His and one Cys residue.
Scope(s) Bacteria
Example(s) Q9KS12 (MARTX_VIBCH);

Propagated annotation [?]

Keywords [?]

Features [?]

From: PS51771
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C80 #"
ACT_SITE 72 72 H 1
ACT_SITE 116 116 /note="Nucleophile" C 1

Additional information [?]

Size range 198-218 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]