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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01107


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01107
General rule information [?]

Accession PRU01107
Dates 21-AUG-2015 (Created)
03-JUN-2021 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51771; CGT_MARTX_CPD
Name CGT/MARTX cysteine protease (CPD) domain
Function The clostridial glucosylating toxins (CGTs) produced by Gram- positive bacteria and the multifunctional-autoprocessing RTX (MARTX) toxins of Gram-negative bacteria carry an embedded cysteine protease domain (CPD) that is regulated by a unique allosteric activation mechanism. The CGT/MARTX CPD catalytic dyad is composed of one His and one Cys residue.
Scope(s) Bacteria
Peptoclostridium
Example(s) Q9KS12;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
Thiol protease
Toxin
end case

Features [?]

From: PS51771
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C80 #"
ACT_SITE 72 72 H 1
ACT_SITE 116 116 /note="Nucleophile" C 1

Additional information [?]

Size range 198-218 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]