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annotation rule: PRU01107

General rule information [?]

Accession PRU01107
Dates 21-AUG-2015 (Created)
3-JUN-2021 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51771; CGT_MARTX_CPD
Name CGT/MARTX cysteine protease (CPD) domain
Function The clostridial glucosylating toxins (CGTs) produced by Gram- positive bacteria and the multifunctional-autoprocessing RTX (MARTX) toxins of Gram-negative bacteria carry an embedded cysteine protease domain (CPD) that is regulated by a unique allosteric activation mechanism. The CGT/MARTX CPD catalytic dyad is composed of one His and one Cys residue.

Propagated annotation [?]


Keywords [?]

case <FTGroup:1>
Hydrolase
Protease
Thiol protease
Toxin
end case


Features [?]

From: PS51771
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C80 #        
ACT_SITE     72     72             H   1
ACT_SITE     116     116       Nucleophile     C   1

Additional information [?]

Size range 198-218 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9KS12 (MARTX_VIBCH)
Scope
Bacteria; Peptoclostridium
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]