ProRule PRU01107
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01107 |
| Accession | PRU01107 |
| Dates | 21-AUG-2015 (Created)
3-JUN-2021 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51771; CGT_MARTX_CPD |
Name | CGT/MARTX cysteine protease (CPD) domain |
| Function | The clostridial glucosylating toxins (CGTs) produced by Gram- positive bacteria and the multifunctional-autoprocessing RTX (MARTX) toxins of Gram-negative bacteria carry an embedded cysteine protease domain (CPD) that is regulated by a unique allosteric activation mechanism. The CGT/MARTX CPD catalytic dyad is composed of one His and one Cys residue. |
| Scope(s) |
Bacteria Peptoclostridium |
| Example(s) | Q9KS12 (MARTX_VIBCH); |
Propagated annotation
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Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| Toxin | |
| end case | |
Features
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| From: PS51771 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C80 #" | |||||||||
| ACT_SITE | 72 | 72 | H | 1 | ||||||||
| ACT_SITE | 116 | 116 | /note="Nucleophile" | C | 1 | |||||||
Additional information
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| Size range | 198-218 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [9] All [ 9 ]
- Retrieve set of proteins with 3D structure for this domain