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annotation rule: PRU01108

General rule information [?]

Accession PRU01108
Dates 25-AUG-2015 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51772; ACD
Name Actin cross-linking (ACD) domain
Function ACDs are enzyme ligases that catalyze the formation of an irreversible iso-peptide bond on two actin molecules in an ATP- and Mg/ Mn(2+)-dependent manner.

Propagated annotation [?]


Keywords [?]

case <FTGroup:1>
ATP-binding
Nucleotide-binding
end case

case <FTGroup:2>
Magnesium
Metal-binding
end case

case <FTGroup:1> and <FTGroup:2>
Ligase
end case


Features [?]

From: PS51772
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ACD #        
NP_BIND     12     16       ATP     S-I-G-[IT]-E   1
METAL     16     16       Magnesium 1; catalytic; for actin cross-linking activity     E   2
METAL     16     16       Magnesium 2; catalytic; for actin cross-linking activity     E   2
METAL     78     78       Magnesium 2; catalytic; for actin cross-linking activity     E   2
METAL     162     162       Magnesium 1; catalytic; for actin cross-linking activity     Q   2
METAL     339     339       Magnesium 1; catalytic; for actin cross-linking activity     E   2
BINDING     81     81       ATP; via carbonyl oxygen     [ST]   1
BINDING     268     268       ATP; via carbonyl oxygen     R   1

Additional information [?]

Size range 425-446 amino acids
Related rules None
Repeats 1
Topology Undefined
Example A0A0H3AIG7 (VGRG1_VIBC3)
Scope
Bacteria; Vibrio
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]