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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01108


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01108
General rule information [?]

Accession PRU01108
Dates 25-AUG-2015 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51772; ACD
Name Actin cross-linking (ACD) domain
Function ACDs are enzyme ligases that catalyze the formation of an irreversible iso-peptide bond on two actin molecules in an ATP- and Mg/ Mn(2+)-dependent manner.
Scope(s) Bacteria
Vibrio
Example(s) A0A0H3AIG7;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
ATP-binding
Nucleotide-binding
end case
case <FTGroup:2>
Magnesium
Metal-binding
end case
case <FTGroup:1> and <FTGroup:2>
Ligase
end case

Features [?]

From: PS51772
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ACD #"
BINDING 12 16 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 S-I-G-[IT]-E 1
BINDING 16 16 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 16 16 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 78 78 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 162 162 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
/ligand_note="catalytic; for actin cross-linking activity"		 Q 2
BINDING 339 339 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
/ligand_note="catalytic; for actin cross-linking activity"		 E 2
BINDING 81 81 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 [ST] 1
BINDING 268 268 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"		 R 1

Additional information [?]

Size range 425-446 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]