General rule information
[?]
Accession |
PRU01108 |
Dates |
25-AUG-2015 (Created) 22-NOV-2019 (Last updated, Version 3) |
Name |
Actin cross-linking (ACD) domain |
Function |
ACDs are enzyme ligases that catalyze the formation of an irreversible iso-peptide bond on two actin molecules in an ATP- and Mg/ Mn(2+)-dependent manner. |
Propagated annotation
[?]
case <FTGroup:1>
end case
case <FTGroup:2>
end case
case <FTGroup:1> and <FTGroup:2>
end case
From: PS51772 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
ACD #
|
|
|
|
|
|
|
NP_BIND
|
|
12
|
|
16
|
|
ATP
|
|
|
|
S-I-G-[IT]-E
|
|
1
|
METAL
|
|
16
|
|
16
|
|
Magnesium 1; catalytic; for actin cross-linking activity
|
|
|
|
E
|
|
2
|
METAL
|
|
16
|
|
16
|
|
Magnesium 2; catalytic; for actin cross-linking activity
|
|
|
|
E
|
|
2
|
METAL
|
|
78
|
|
78
|
|
Magnesium 2; catalytic; for actin cross-linking activity
|
|
|
|
E
|
|
2
|
METAL
|
|
162
|
|
162
|
|
Magnesium 1; catalytic; for actin cross-linking activity
|
|
|
|
Q
|
|
2
|
METAL
|
|
339
|
|
339
|
|
Magnesium 1; catalytic; for actin cross-linking activity
|
|
|
|
E
|
|
2
|
BINDING
|
|
81
|
|
81
|
|
ATP; via carbonyl oxygen
|
|
|
|
[ST]
|
|
1
|
BINDING
|
|
268
|
|
268
|
|
ATP; via carbonyl oxygen
|
|
|
|
R
|
|
1
|
Additional information
[?]
Size range |
425-446 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
A0A0H3AIG7 (VGRG1_VIBC3) |
Scope |
Bacteria; Vibrio |
Comments |
None |
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(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]