We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01122
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01122
General rule information
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| Accession | PRU01122 |
| Dates | 23-DEC-2015 (Created)
08-OCT-2024 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51786; LON_PROTEOLYTIC |
Name | Lon proteolytic domain |
| Function | The Lon proteolytic domain forms peptidase family S16 of clan SJ. It has a serine-lysine catalytic dyad in which a lysine assists the catalytic serine in proteolytic cleavage. |
| Scope(s) |
Eukaryota Bacteria Archaea Methanobacteriati Viruses Mimivirus |
| Example(s) | B7FSL4; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> and <OC:Bacteria> | |
| Protein name | + RecName: EC=3.4.21.53; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; |
| SIMILARITY | Belongs to the peptidase S16 family. |
| else case <FTGroup:1> | |
Keywords
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| Hydrolase | |
| Protease | |
| Serine protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0004252; Molecular function:serine-type endopeptidase activity | |
| GO:0004176; Molecular function:ATP-dependent peptidase activity | |
Features
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| From: PS51786 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Lon proteolytic #" | |||||||||
| ACT_SITE | 91 | 91 | S | 1 | ||||||||
| ACT_SITE | 134 | 134 | K | 1 | ||||||||
Additional information
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| Size range | 169-262 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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