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annotation rule: PRU01126

General rule information [?]

Accession PRU01126
Dates 10-FEB-2016 (Created)
14-MAY-2022 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51790; MSRB
Name Methionine-R-sulfoxide reductase (MsrB) domain
Function MsrB catalyzes the reduction of methionine-R-sulfoxide back to methionine.

Propagated annotation [?]


Description [?]

case <FTTag:Cat>
+ RecName: EC 1.8.4.-;
end case


Comments [?]

Similarity Belongs to the MsrB Met sulfoxide reductase family.

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

case <FTTag:Cat>
GO:0033743; Molecular function: peptide-methionine (R)-S-oxide reductase activity.
GO:0006979; Biological process: response to oxidative stress.

Keywords [?]

Oxidoreductase
end case

case <FTGroup:1>
Metal-binding
Zinc
end case


Features [?]

From: PS51790
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MsrB #        
ACT_SITE     112     112       Nucleophile   Cat   [CU]  
BINDING     40     40       /ligand="Zn(2+)" /ligand_id="29105     C   1
BINDING     43     43       /ligand="Zn(2+)" /ligand_id="29105     C   1
BINDING     89     89       /ligand="Zn(2+)" /ligand_id="29105     C   1
BINDING     92     92       /ligand="Zn(2+)" /ligand_id="29105     C   1

Additional information [?]

Size range 94-145 amino acids
Related rules None
Repeats 1
Topology Undefined
Example A8A0X0 (MSRB_ECOHS)
Scope
Bacteria
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]