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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01126


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01126
General rule information [?]

Accession PRU01126
Dates 10-FEB-2016 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51790; MSRB
Name Methionine-R-sulfoxide reductase (MsrB) domain
Function MsrB catalyzes the reduction of methionine-R-sulfoxide back to methionine.
Scope(s) Bacteria
Eukaryota
Example(s) A8A0X0;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:Cat>
Protein name + RecName: EC=1.8.4.-;
end case

Comments [?]

SIMILARITYBelongs to the MsrB Met sulfoxide reductase family.

Keywords [?]

Oxidoreductase
end case
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
case <FTTag:Cat>
GO:0033743; Molecular function:peptide-methionine (R)-S-oxide reductase activity
GO:0006979; Biological process:response to oxidative stress

Features [?]

From: PS51790
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MsrB #"
ACT_SITE 112 112 /note="Nucleophile" Cat [CU]
BINDING 40 40 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 43 43 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 89 89 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 92 92 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 94-145 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]