We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01140
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01140
General rule information
[?]
| Accession | PRU01140 |
| Dates | 24-MAY-2016 (Created)
22-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51799; ZF_C2H2_AKAP95 |
Name | Zinc finger C2H2 AKAP95-type |
| Function | AKAP95 harbours two zinc fingers, designated ZF1 and ZF2. ZF1 mediates the binding of AKAP95 to DNA. ZF2 is dispensable for chromatin binding; however it may substitute for ZF1 when the latter is rendered non- functional by mutation. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | O88291; |
Propagated annotation
[?]
Comments
[?]
| SIMILARITY | Belongs to the AKAP95 family. |
Keywords
[?]
| case <Feature:PS51799:1=[CH]> and <Feature:PS51799:4=[CH]> and <Feature:PS51799:18=[CH]> and <Feature:PS51799:24=[CH]> | |
| Metal-binding | |
| Zinc | |
| end case | |
| Zinc-finger | |
Features
[?]
| From: PS51799 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51799:1=[C]> and <Feature:PS51799:4=[C]> and <Feature:PS51799:18=[H]> and <Feature:PS51799:24=[H]> | ||||||||||||
| ZN_FING | from | to | /note="C2H2 AKAP95-type #" | |||||||||
| else case <Feature:PS51799:1=[CH]> and <Feature:PS51799:4=[CH]> and <Feature:PS51799:18=[CH]> and <Feature:PS51799:24=[CH]> | ||||||||||||
| ZN_FING | from | to | /note="C2H2 AKAP95-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="C2H2 AKAP95-type #; degenerate" | |||||||||
| end case | ||||||||||||
Additional information
[?]
| Size range | 13-34 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [14] All [ 14 ]
- Retrieve set of proteins with 3D structure for this domain