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ProRule PRU01140


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01140
Accession PRU01140
Dates 24-MAY-2016 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51799; ZF_C2H2_AKAP95
Name Zinc finger C2H2 AKAP95-type
Function AKAP95 harbours two zinc fingers, designated ZF1 and ZF2. ZF1 mediates the binding of AKAP95 to DNA. ZF2 is dispensable for chromatin binding; however it may substitute for ZF1 when the latter is rendered non- functional by mutation.
Scope(s) Eukaryota
Euteleostomi
Example(s) O88291 (ZN326_MOUSE);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the AKAP95 family.

Keywords [?]

case <Feature:PS51799:1=[CH]> and <Feature:PS51799:4=[CH]> and <Feature:PS51799:18=[CH]> and <Feature:PS51799:24=[CH]>
Metal-binding
Zinc
end case
Zinc-finger

Features [?]

From: PS51799
Key From To Description Tag Condition FTGroup
case <Feature:PS51799:1=[C]> and <Feature:PS51799:4=[C]> and <Feature:PS51799:18=[H]> and <Feature:PS51799:24=[H]>
ZN_FING from to /note="C2H2 AKAP95-type #"
else case <Feature:PS51799:1=[CH]> and <Feature:PS51799:4=[CH]> and <Feature:PS51799:18=[CH]> and <Feature:PS51799:24=[CH]>
ZN_FING from to /note="C2H2 AKAP95-type #; atypical"
else
ZN_FING from to /note="C2H2 AKAP95-type #; degenerate"
end case

Additional information [?]

Size range 13-34 amino acids
Related rules None
Fusion None
Repeats 2
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]