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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01146


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01146
General rule information [?]

Accession PRU01146
Dates 06-JUL-2016 (Created)
22-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51805; EPHD
Name Extended PHD (ePHD) domain
Function The extended plant homeodomain (ePHD) domain contains an N-terminal pre-PHD (C2HC zinc finger), a long linker, and a noncanonical PHD finger (C4HC3 zinc finger). The ePHD domain can bind dsDNA but not histones.
Scope(s) Eukaryota
Example(s) P20659;

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
Zinc-finger
end case

Gene Ontology [?]

case (<Feature:PS51805:4=[CH]> and <Feature:PS51805:7=[CH]> and <Feature:PS51805:27=[CH]> and <Feature:PS51805:30=[CH]>) or (<Feature:PS51805:63=[CH]> and <Feature:PS51805:66=[CH]> and <Feature:PS51805:85=[CH]> and <Feature:PS51805:88=[CH]>) or (<Feature:PS51805:75=[CH]> and <Feature:PS51805:80=[CH]> and <Feature:PS51805:109=[CH]> and <Feature:PS51805:112=[CH]>)
GO:0008270; Molecular function:zinc ion binding
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51805
Key From To Description Tag Condition FTGroup
case <Feature:PS51805:4=C> and <Feature:PS51805:7=C> and <Feature:PS51805:27=H> and <Feature:PS51805:30=C>
ZN_FING from 37 /note="C2HC pre-PHD-type #"
else case <Feature:PS51805:4=[CH]> and <Feature:PS51805:7=[CH]> and <Feature:PS51805:27=[CH]> and <Feature:PS51805:30=[CH]>
ZN_FING from 37 /note="C2HC pre-PHD-type #; atypical"
else
ZN_FING from 37 /note="C2HC pre-PHD-type #; degenerate"
end case
case (<Feature:PS51805:63=[C]> and <Feature:PS51805:66=[C]> and <Feature:PS51805:85=[H]> and <Feature:PS51805:88=[C]>) and (<Feature:PS51805:75=[C]> and <Feature:PS51805:80=[C]> and <Feature:PS51805:109=[C]> and <Feature:PS51805:112=[H]>)
ZN_FING 61 to /note="PHD-type #"
else case (<Feature:PS51805:63=[CH]> and <Feature:PS51805:66=[CH]> and <Feature:PS51805:85=[CH]> and <Feature:PS51805:88=[CH]>) and (<Feature:PS51805:75=[CH]> and <Feature:PS51805:80=[CH]> and <Feature:PS51805:109=[CH]> and <Feature:PS51805:112=[CH]>)
ZN_FING 61 to /note="PHD-type #; atypical"
else
ZN_FING 61 to /note="PHD-type #; degenerate"
end case
case not <AnyFeature:PS50016~1,10~PS51805>
REGION from to /note="Extended PHD# domain (ePHD#)"
end case

Additional information [?]

Size range 95-155 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]