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annotation rule: PRU01162

General rule information [?]

Accession PRU01162
Dates 21-OCT-2016 (Created)
22-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51818; HOMEO_PROSPERO
Name Homeo-Prospero (HPD) domain
Function The HPD domain is required for nearly all the known functions of Prospero, including regulation of nuclear/cytoplasmic localization, sequence- specific DNA binding, and transcriptional activation.

Propagated annotation [?]


Comments [?]

Domain The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
Similarity Belongs to the Prospero homeodomain family.

Gene Ontology [?]

GO:0006351; Biological process: transcription, DNA-templated.
GO:0003677; Molecular function: DNA binding.
GO:0045944; Biological process: positive regulation of transcription by RNA polymerase II.
GO:0001227; Molecular function: DNA-binding transcription repressor activity, RNA polymerase II-specific.
GO:0000122; Biological process: negative regulation of transcription by RNA polymerase II.

Keywords [?]


Features [?]

From: PS51818
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     59       Prospero-type homeo #        
DOMAIN     60     to       Prospero #        
REGION     from     to       Homeo-Prospero #        

Additional information [?]

Size range 146-169 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q91018 (PROX1_CHICK)
Scope
Eukaryota; Metazoa
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]