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ProRule PRU01162


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01162
Accession PRU01162
Dates 21-OCT-2016 (Created)
27-JUN-2022 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51818; HOMEO_PROSPERO
Name Homeo-Prospero (HPD) domain
Function The HPD domain is required for nearly all the known functions of Prospero, including regulation of nuclear/cytoplasmic localization, sequence- specific DNA binding, and transcriptional activation.
Scope(s) Eukaryota
Metazoa
Example(s) Q91018 (PROX1_CHICK);

Propagated annotation [?]

Comments [?]

DOMAINThe Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
SIMILARITYBelongs to the Prospero homeodomain family.

Keywords [?]

DNA-binding
Homeobox
Transcription
Transcription regulation

Gene Ontology [?]

GO:0006351; Biological process:DNA-templated transcription
GO:0003677; Molecular function:DNA binding
GO:0045944; Biological process:positive regulation of transcription by RNA polymerase II
GO:0001227; Molecular function:DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0000122; Biological process:negative regulation of transcription by RNA polymerase II

Features [?]

From: PS51818
Key From To Description Tag Condition FTGroup
DOMAIN from 59 /note="Prospero-type homeo #"
DOMAIN 60 to /note="Prospero #"
REGION from to /note="Homeo-Prospero #"

Additional information [?]

Size range 146-169 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]