PRU01162

Accession	PRU01162
Dates	21-OCT-2016 (Created) 27-JUN-2022 (Last updated, Version 7)

Data class

Domain

Predictors

PROSITE; PS51818; HOMEO_PROSPERO

Name	Homeo-Prospero (HPD) domain

Function

The HPD domain is required for nearly all the known functions of Prospero, including regulation of nuclear/cytoplasmic localization, sequence- specific DNA binding, and transcriptional activation.

Domain	The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain.
Similarity	Belongs to the Prospero homeodomain family.

GO:0006351; Biological process: DNA-templated transcription.
GO:0003677; Molecular function: DNA binding.
GO:0045944; Biological process: positive regulation of transcription by RNA polymerase II.
GO:0001227; Molecular function: DNA-binding transcription repressor activity, RNA polymerase II-specific.
GO:0000122; Biological process: negative regulation of transcription by RNA polymerase II.

DNA-binding
Homeobox
Transcription
Transcription regulation

From: PS51818

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

59

Prospero-type homeo #

DOMAIN

60

to

Prospero #

REGION

from

to

Homeo-Prospero #

Size range	146-169 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q91018 (PROX1_CHICK)
Scope	Eukaryota; Metazoa
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

• UniProtKB/Swiss-Prot sets
  

  Eukaryota

  [8]

  
  
• Retrieve set of proteins with 3D structure for this domain