ProRule PRU01162
General rule information
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| Accession | PRU01162 |
| Dates | 21-OCT-2016 (Created)
27-JUN-2022 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51818; HOMEO_PROSPERO |
Name | Homeo-Prospero (HPD) domain |
| Function | The HPD domain is required for nearly all the known functions of Prospero, including regulation of nuclear/cytoplasmic localization, sequence- specific DNA binding, and transcriptional activation. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q91018 (PROX1_CHICK); |
Propagated annotation
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Comments
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| DOMAIN | The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. |
| SIMILARITY | Belongs to the Prospero homeodomain family. |
Keywords
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Gene Ontology
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| GO:0006351; Biological process:DNA-templated transcription |
| GO:0003677; Molecular function:DNA binding |
| GO:0045944; Biological process:positive regulation of transcription by RNA polymerase II |
| GO:0001227; Molecular function:DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000122; Biological process:negative regulation of transcription by RNA polymerase II |
Features
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| From: PS51818 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | 59 | /note="Prospero-type homeo #" | |||||||||
| DOMAIN | 60 | to | /note="Prospero #" | |||||||||
| REGION | from | to | /note="Homeo-Prospero #" | |||||||||
Additional information
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| Size range | 146-169 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain