We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01162
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01162
General rule information
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| Accession | PRU01162 |
| Dates | 21-OCT-2016 (Created)
27-JUN-2022 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51818; HOMEO_PROSPERO |
Name | Homeo-Prospero (HPD) domain |
| Function | The HPD domain is required for nearly all the known functions of Prospero, including regulation of nuclear/cytoplasmic localization, sequence- specific DNA binding, and transcriptional activation. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q91018; |
Propagated annotation
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Comments
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| DOMAIN | The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. |
| SIMILARITY | Belongs to the Prospero homeodomain family. |
Keywords
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Gene Ontology
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| GO:0006351; Biological process:DNA-templated transcription |
| GO:0003677; Molecular function:DNA binding |
| GO:0045944; Biological process:positive regulation of transcription by RNA polymerase II |
| GO:0001227; Molecular function:DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000122; Biological process:negative regulation of transcription by RNA polymerase II |
Features
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| From: PS51818 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | 59 | /note="Prospero-type homeo #" | |||||||||
| DOMAIN | 60 | to | /note="Prospero #" | |||||||||
| REGION | from | to | /note="Homeo-Prospero #" | |||||||||
Additional information
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| Size range | 146-169 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [8] All [ 8 ]
- Retrieve set of proteins with 3D structure for this domain