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| annotation rule: PRU01162 |
General rule information
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| Accession | PRU01162 |
| Dates | 21-OCT-2016 (Created) 22-NOV-2019 (Last updated, Version 6) |
| Data class | Domain |
| Predictors | PROSITE; PS51818; HOMEO_PROSPERO |
| Name | Homeo-Prospero (HPD) domain |
| Function | The HPD domain is required for nearly all the known functions of Prospero, including regulation of nuclear/cytoplasmic localization, sequence- specific DNA binding, and transcriptional activation. |
Propagated annotation
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Comments
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| Domain | The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. |
| Similarity | Belongs to the Prospero homeodomain family. |
Gene Ontology
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GO:0006351; Biological process: transcription, DNA-templated.
GO:0003677; Molecular function: DNA binding.
GO:0045944; Biological process: positive regulation of transcription by RNA polymerase II.
GO:0001227; Molecular function: DNA-binding transcription repressor activity, RNA polymerase II-specific.
GO:0000122; Biological process: negative regulation of transcription by RNA polymerase II.
GO:0003677; Molecular function: DNA binding.
GO:0045944; Biological process: positive regulation of transcription by RNA polymerase II.
GO:0001227; Molecular function: DNA-binding transcription repressor activity, RNA polymerase II-specific.
GO:0000122; Biological process: negative regulation of transcription by RNA polymerase II.
Keywords
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Features
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| From: PS51818 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | 59 | Prospero-type homeo # | |||||||||
| DOMAIN | 60 | to | Prospero # | |||||||||
| REGION | from | to | Homeo-Prospero # | |||||||||
Additional information
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| Size range | 146-169 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q91018 (PROX1_CHICK) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [8]
- Retrieve set of proteins with 3D structure for this domain