We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01163
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01163
General rule information
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| Accession | PRU01163 |
| Dates | 01-NOV-2016 (Created)
19-NOV-2022 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51819; VOC |
Name | Vicinal oxygen chelate (VOC) domain |
| Function | The vicinal oxygen chelate (VOC) family of enzymes catalyzes a highly diverse set of chemistries that derives from one common mechanistic trait: bidentate coordination to a divalent metal center by a substrate or intermediate or transition state through vicinal oxygen atoms. |
| Scope(s) |
Bacteria Eukaryota Archaea Pyrococcus |
| Example(s) | Q8GPH6; |
Propagated annotation
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Keywords
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| case <FTGroup:1> | |
| Metal-binding | |
| end case | |
Features
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| From: PS51819 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="VOC #" | |||||||||
| ACT_SITE | 118 | 118 | /note="Proton donor/acceptor" | [EV] | ||||||||
| BINDING | 4 | 4 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
[HQ] | 1 | |||||||
| BINDING | 45 | 45 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
E | 1 | |||||||
| BINDING | 70 | 70 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
[HQ] | 1 | |||||||
| BINDING | 118 | 118 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
[EV] | 1 | |||||||
Additional information
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| Size range | 68-190 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [1] Bacteria [146] Eukaryota [64] All [ 211 ]
- Retrieve set of proteins with 3D structure for this domain