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ProRule PRU01183


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01183
Accession PRU01183
Dates 14-JUL-2017 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51838; HDAG
Name Hepatitis delta antigen (HDAg) domain
Function The C-terminus of the HDAg domain forms the RNAPII-binding motif conserved in humans and virus, while the NELF-C (or NELF-D)-binding region of NELF-A is localized in the middle of the HDAg domain. The region of HDAg corresponding to the NELF-C (or NELF-D)-binding region of NELF-A has an RNA- binding function.
Scope(s) Viruses
Deltavirus
Eukaryota
Metazoa
Example(s) P0C6L6 (LHDAG_HDVIT);

Propagated annotation [?]

Features [?]

From: PS51838
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HDAg #"
case <OS:Deltavirus>
REGION 64 74 /note="RNA-binding"
REGION 107 117 /note="RNA-binding"
end case
case <OC:Metazoa>
REGION 37 100 /note="NELF-C/D-binding"
end case
REGION 101 to /note="RNAPII-binding"

Additional information [?]

Size range 150-186 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]