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annotation rule: PRU01183

General rule information [?]

Accession PRU01183
Dates 14-JUL-2017 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51838; HDAG
Name Hepatitis delta antigen (HDAg) domain
Function The C-terminus of the HDAg domain forms the RNAPII-binding motif conserved in humans and virus, while the NELF-C (or NELF-D)-binding region of NELF-A is localized in the middle of the HDAg domain. The region of HDAg corresponding to the NELF-C (or NELF-D)-binding region of NELF-A has an RNA- binding function.

Propagated annotation [?]


Features [?]

From: PS51838
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       HDAg #        
case <OS:Deltavirus>
REGION     64     74       RNA-binding        
REGION     107     117       RNA-binding        
end case

case <OC:Metazoa>
REGION     37     100       NELF-C/D-binding        
end case

REGION     101     to       RNAPII-binding        

Additional information [?]

Size range 150-186 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6L6 (LHDAG_HDVIT)
Scope
Viruses; Deltavirus
Eukaryota; Metazoa
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]