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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01183


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01183
General rule information [?]

Accession PRU01183
Dates 14-JUL-2017 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51838; HDAG
Name Hepatitis delta antigen (HDAg) domain
Function The C-terminus of the HDAg domain forms the RNAPII-binding motif conserved in humans and virus, while the NELF-C (or NELF-D)-binding region of NELF-A is localized in the middle of the HDAg domain. The region of HDAg corresponding to the NELF-C (or NELF-D)-binding region of NELF-A has an RNA- binding function.
Scope(s) Viruses
Deltavirus
Eukaryota
Metazoa
Example(s) P0C6L6;

Propagated annotation [?]

Features [?]

From: PS51838
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HDAg #"
case <OS:Deltavirus>
REGION 64 74 /note="RNA-binding"
REGION 107 117 /note="RNA-binding"
end case
case <OC:Metazoa>
REGION 37 100 /note="NELF-C/D-binding"
end case
REGION 101 to /note="RNAPII-binding"

Additional information [?]

Size range 150-186 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]