ProRule PRU01191

General rule information [?]

Accession PRU01191
Dates 27-OCT-2017 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS50985; GRAS
Name GRAS domain
Function The GRAS domain is typically composed of ~380 amino acids and contains five highly conserved motifs, found in the following order: leucine heptad repeat I (LRI), the VHIID motif, leucine heptad repeat II (LRII), the PFYRE motif and the SAW motif.
Scope(s) Eukaryota
Example(s) Q6EI06 (GAIP_CUCMA);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the GRAS family.

Features [?]

From: PS50985
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GRAS #"
REGION 8 68 /note="Leucine repeat I (LRI)"
REGION 87 152 /note="VHIID"
REGION 168 200 /note="Leucine repeat II (LRII)"
REGION 210 301 /note="PFYRE"
REGION 304 to /note="SAW"
MOTIF 15 19 /note="LxCxE motif" L-x-C-x-E
MOTIF 118 122 /note="VHIID" [VILFP]-H-[IV]-[ILV]-D
MOTIF 218 222 /note="LXXLL motif" L-x-x-[LV]-L

Additional information [?]

Size range 350-430 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]