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General rule information [?]

Accession PRU01191
Dates 27-OCT-2017 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS50985; GRAS
Name GRAS domain
Function The GRAS domain is typically composed of ~380 amino acids and contains five highly conserved motifs, found in the following order: leucine heptad repeat I (LRI), the VHIID motif, leucine heptad repeat II (LRII), the PFYRE motif and the SAW motif.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the GRAS family.

Features [?]

From: PS50985
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       GRAS #        
REGION     8     68       Leucine repeat I (LRI)        
REGION     87     152       VHIID        
REGION     168     200       Leucine repeat II (LRII)        
REGION     210     301       PFYRE        
REGION     304     to       SAW        
MOTIF     15     19       LxCxE motif     L-x-C-x-E  
MOTIF     118     122       VHIID     [VILFP]-H-[IV]-[ILV]-D  
MOTIF     218     222       LXXLL motif     L-x-x-[LV]-L  

Additional information [?]

Size range 350-430 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6EI06 (GAIP_CUCMA)
Eukaryota; Magnoliopsida
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]