We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01191
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01191
General rule information
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| Accession | PRU01191 |
| Dates | 27-OCT-2017 (Created)
22-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50985; GRAS |
Name | GRAS domain |
| Function | The GRAS domain is typically composed of ~380 amino acids and contains five highly conserved motifs, found in the following order: leucine heptad repeat I (LRI), the VHIID motif, leucine heptad repeat II (LRII), the PFYRE motif and the SAW motif. |
| Scope(s) |
Eukaryota Magnoliopsida |
| Example(s) | Q6EI06; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the GRAS family. |
Features
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| From: PS50985 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GRAS #" | |||||||||
| REGION | 8 | 68 | /note="Leucine repeat I (LRI)" | |||||||||
| REGION | 87 | 152 | /note="VHIID" | |||||||||
| REGION | 168 | 200 | /note="Leucine repeat II (LRII)" | |||||||||
| REGION | 210 | 301 | /note="PFYRE" | |||||||||
| REGION | 304 | to | /note="SAW" | |||||||||
| MOTIF | 15 | 19 | /note="LxCxE motif" | L-x-C-x-E | ||||||||
| MOTIF | 118 | 122 | /note="VHIID" | [VILFP]-H-[IV]-[ILV]-D | ||||||||
| MOTIF | 218 | 222 | /note="LXXLL motif" | L-x-x-[LV]-L | ||||||||
Additional information
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| Size range | 350-430 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [79] All [ 79 ]
- Retrieve set of proteins with 3D structure for this domain