ProRule PRU01191
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01191 |
| Accession | PRU01191 |
| Dates | 27-OCT-2017 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50985; GRAS |
Name | GRAS domain |
| Function | The GRAS domain is typically composed of ~380 amino acids and contains five highly conserved motifs, found in the following order: leucine heptad repeat I (LRI), the VHIID motif, leucine heptad repeat II (LRII), the PFYRE motif and the SAW motif. |
| Scope(s) |
Eukaryota Magnoliopsida |
| Example(s) | Q6EI06 (GAIP_CUCMA); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the GRAS family. |
Features
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| From: PS50985 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GRAS #" | |||||||||
| REGION | 8 | 68 | /note="Leucine repeat I (LRI)" | |||||||||
| REGION | 87 | 152 | /note="VHIID" | |||||||||
| REGION | 168 | 200 | /note="Leucine repeat II (LRII)" | |||||||||
| REGION | 210 | 301 | /note="PFYRE" | |||||||||
| REGION | 304 | to | /note="SAW" | |||||||||
| MOTIF | 15 | 19 | /note="LxCxE motif" | L-x-C-x-E | ||||||||
| MOTIF | 118 | 122 | /note="VHIID" | [VILFP]-H-[IV]-[ILV]-D | ||||||||
| MOTIF | 218 | 222 | /note="LXXLL motif" | L-x-x-[LV]-L | ||||||||
Additional information
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| Size range | 350-430 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [79] All [ 79 ]
- Retrieve set of proteins with 3D structure for this domain