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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01194


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01194
General rule information [?]

Accession PRU01194
Dates 16-NOV-2017 (Created)
22-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51847; SMP
Name Synaptotagmin-like mitochondrial lipid-binding proteins (SMP) domain
Function The SMP domain is able to homo- or heterodimerize, harbors lipids in a hydrophobic cavity and mediates lipid transfer between two adjacent bilayers independently of membrane fusion and fission reactions.
Scope(s) Eukaryota
Example(s) C5DLL1;

Propagated annotation [?]

Comments [?]

DOMAINThe SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

Keywords [?]

Membrane
Transport
Lipid-binding
Lipid transport

Features [?]

From: PS51847
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="SMP-LTD #"

Additional information [?]

Size range 150-700 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]