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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01205


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01205
General rule information [?]

Accession PRU01205
Dates 20-FEB-2018 (Created)
05-JAN-2023 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51858; PPPDE
Name PPPDE domain
Function The PPPDE domain has a papain-like fold, in which a catalytic dyad is formed by a conserved N-terminal histidine residue on a beta-strand (beta2) and a conserved C-terminal cysteine residue on a following alpha- helix (alpha3).
Scope(s) Eukaryota
Viruses
Reovirales
Example(s) Q9D291;

Propagated annotation [?]

Keywords [?]

Hydrolase
Protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008233; Molecular function:peptidase activity

Features [?]

From: PS51858
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PPPDE #"
ACT_SITE 32 32 H 1
ACT_SITE 107 107 C 1

Additional information [?]

Size range 130-230 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]