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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01216


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01216
General rule information [?]

Accession PRU01216
Dates 25-JUL-2018 (Created)
22-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51868; PEPTIDASE_S39
Name Peptidase family S39 domain
Function A triad composed of a histidine, an aspartate and a serine residue constitute the active centre of the peptidase S39 family domain.
Scope(s) Viruses
Riboviria
Example(s) O73564;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name Contains:
RecName: Full=Serine protease;
                 EC=3.4.21.-;

Keywords [?]

Hydrolase
Protease
Serine protease
end case

Gene Ontology [?]

GO:0004252; Molecular function:serine-type endopeptidase activity

Features [?]

From: PS51868
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S39 #"
ACT_SITE 49 49 /note="For protease activity" H 1
ACT_SITE 83 83 /note="For protease activity" D 1
ACT_SITE 153 153 /note="For protease activity" S 1

Additional information [?]

Size range 180-200 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]