ProRule PRU01230

General rule information [?]

Accession PRU01230
Dates 7-JAN-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51882; G_ALPHA
Name G-alpha domain
Function The G-alpha domain contains a binding site for guanine nucleotide and possesses GTPase activity.
Scope(s) Eukaryota
Example(s) P87032 (GPA1_USTMA);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0031683; Molecular function:G-protein beta/gamma-subunit complex binding
GO:0003924; Molecular function:GTPase activity
GO:0005525; Molecular function:GTP binding
case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding
end case
GO:0005834; Cellular component:heterotrimeric G-protein complex

Features [?]

From: PS51882
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="G-alpha #"
REGION 4 17 /note="G1 motif"
REGION 146 154 /note="G2 motif"
REGION 169 178 /note="G3 motif"
REGION 238 245 /note="G4 motif"
REGION 298 303 /note="G5 motif"
BINDING 16 16 /ligand="a divalent metal cation"
S 1
BINDING 154 154 /ligand="a divalent metal cation"
T 1

Additional information [?]

Size range 310-490 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]