We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01230
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01230
General rule information
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| Accession | PRU01230 |
| Dates | 07-JAN-2019 (Created)
19-NOV-2022 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51882; G_ALPHA |
Name | G-alpha domain |
| Function | The G-alpha domain contains a binding site for guanine nucleotide and possesses GTPase activity. |
| Scope(s) |
Eukaryota |
| Example(s) | P87032; |
Propagated annotation
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Keywords
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| GTP-binding | |
| Nucleotide-binding | |
| Transducer | |
| case <FTGroup:1> | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0031683; Molecular function:G-protein beta/gamma-subunit complex binding | |
| GO:0003924; Molecular function:GTPase activity | |
| GO:0005525; Molecular function:GTP binding | |
| case <FTGroup:1> | |
| GO:0046872; Molecular function:metal ion binding | |
| end case | |
| GO:0005834; Cellular component:heterotrimeric G-protein complex | |
Features
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| From: PS51882 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="G-alpha #" | |||||||||
| REGION | 4 | 17 | /note="G1 motif" | |||||||||
| REGION | 146 | 154 | /note="G2 motif" | |||||||||
| REGION | 169 | 178 | /note="G3 motif" | |||||||||
| REGION | 238 | 245 | /note="G4 motif" | |||||||||
| REGION | 298 | 303 | /note="G5 motif" | |||||||||
| BINDING | 16 | 16 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
S | 1 | |||||||
| BINDING | 154 | 154 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" |
T | 1 | |||||||
Additional information
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| Size range | 310-490 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [203] All [ 203 ]
- Retrieve set of proteins with 3D structure for this domain