PRU01246

Accession	PRU01246
Dates	11-JUL-2019 (Created) 22-NOV-2019 (Last updated, Version 2)

Data class

Domain

Predictors

PROSITE; PS51898; TYR_RECOMBINASE

Name	Tyrosine recombinase domain

Function

Tyrosine-type site-specific recombinases catalyze a variety of sequence-specific DNA rearrangement in biological systems, including the integration and excision of phage genomes into and out of their bacterial hosts, conjugative transposition, resolution of catenated DNA circles, regulation of plasmid copy number, DNA excision to control gene expression for nitrogen fixation in Anabaena and DNA inversions controlling expression of cell surface proteins or DNA replication.

Similarity

Belongs to the 'phage' integrase family.

GO:0003677; Molecular function: DNA binding.
GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.

DNA recombination

From: PS51898

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

Tyr recombinase #

ACT_SITE

41

41

R

ACT_SITE

66

66

K

ACT_SITE

134

134

H

ACT_SITE

137

137

R

ACT_SITE

160

160

[HW]

ACT_SITE

170

170

O-(3'-phospho-DNA)-tyrosine intermediate

Y

Size range	140-220 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P9WMB3 (INT2_MYCTU)
Scope	Bacteria Viruses Archaea
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

• UniProtKB/Swiss-Prot sets
  

  Archaea	[9]
  Bacteria	[428]
  Viruses	[23]
  All	[ 460 ]

  
  
• Retrieve set of proteins with 3D structure for this domain