ProRule PRU01246

General rule information [?]

Accession PRU01246
Dates 11-JUL-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Name Tyrosine recombinase domain
Function Tyrosine-type site-specific recombinases catalyze a variety of sequence-specific DNA rearrangement in biological systems, including the integration and excision of phage genomes into and out of their bacterial hosts, conjugative transposition, resolution of catenated DNA circles, regulation of plasmid copy number, DNA excision to control gene expression for nitrogen fixation in Anabaena and DNA inversions controlling expression of cell surface proteins or DNA replication.
Scope(s) Bacteria
Example(s) P9WMB3 (INT2_MYCTU);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the 'phage' integrase family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0009037; Molecular function:tyrosine-based site-specific recombinase activity

Features [?]

From: PS51898
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Tyr recombinase #"
ACT_SITE 41 41 R
ACT_SITE 66 66 K
ACT_SITE 134 134 H
ACT_SITE 137 137 R
ACT_SITE 160 160 [HW]
ACT_SITE 170 170 /note="O-(3'-phospho-DNA)-tyrosine intermediate" Y

Additional information [?]

Size range 140-220 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]