We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01246
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01246
General rule information
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| Accession | PRU01246 |
| Dates | 11-JUL-2019 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51898; TYR_RECOMBINASE |
Name | Tyrosine recombinase domain |
| Function | Tyrosine-type site-specific recombinases catalyze a variety of sequence-specific DNA rearrangement in biological systems, including the integration and excision of phage genomes into and out of their bacterial hosts, conjugative transposition, resolution of catenated DNA circles, regulation of plasmid copy number, DNA excision to control gene expression for nitrogen fixation in Anabaena and DNA inversions controlling expression of cell surface proteins or DNA replication. |
| Scope(s) |
Bacteria Viruses Archaea |
| Example(s) | P9WMB3; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the 'phage' integrase family. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0009037; Molecular function:tyrosine-based site-specific recombinase activity |
Features
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| From: PS51898 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Tyr recombinase #" | |||||||||
| ACT_SITE | 41 | 41 | R | |||||||||
| ACT_SITE | 66 | 66 | K | |||||||||
| ACT_SITE | 134 | 134 | H | |||||||||
| ACT_SITE | 137 | 137 | R | |||||||||
| ACT_SITE | 160 | 160 | [HW] | |||||||||
| ACT_SITE | 170 | 170 | /note="O-(3'-phospho-DNA)-tyrosine intermediate" | Y | ||||||||
Additional information
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| Size range | 140-220 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [9] Bacteria [428] Viruses [23] All [ 460 ]
- Retrieve set of proteins with 3D structure for this domain