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annotation rule: PRU01246

General rule information [?]

Accession PRU01246
Dates 11-JUL-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Name Tyrosine recombinase domain
Function Tyrosine-type site-specific recombinases catalyze a variety of sequence-specific DNA rearrangement in biological systems, including the integration and excision of phage genomes into and out of their bacterial hosts, conjugative transposition, resolution of catenated DNA circles, regulation of plasmid copy number, DNA excision to control gene expression for nitrogen fixation in Anabaena and DNA inversions controlling expression of cell surface proteins or DNA replication.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the 'phage' integrase family.

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.

Keywords [?]

Features [?]

From: PS51898
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Tyr recombinase #        
ACT_SITE     41     41             R  
ACT_SITE     66     66             K  
ACT_SITE     134     134             H  
ACT_SITE     137     137             R  
ACT_SITE     160     160             [HW]  
ACT_SITE     170     170       O-(3'-phospho-DNA)-tyrosine intermediate     Y  

Additional information [?]

Size range 140-220 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P9WMB3 (INT2_MYCTU)
Comments None


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UniProtKB rule member sequences [?]