We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01247
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01247
General rule information
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| Accession | PRU01247 |
| Dates | 03-JUL-2019 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51899; TYR_RECOMBINASE_FLP |
Name | Flp-type tyrosine recombinase domain |
| Function | The yeast Flp recombinase is a tyrosine site-specific recombinase responsible for the control of plasmid copy number. All members of the tyrosine, or lambda integrase family of site-specific recombinases proceed via a 3' covalent phosphotyrosine intermediate to catalyze a variety of DNA rearrangements, including insertions, deletions, and inversions, depending on the location and orientation of cognate recombination target sites. |
| Scope(s) |
Eukaryota Saccharomycetaceae |
| Example(s) | P13769; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the 'phage' integrase family. |
Keywords
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| DNA integration | |
| DNA recombination | |
| end case | |
Gene Ontology
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| case <FT:2> | |
| GO:0015074; Biological process:DNA integration | |
| GO:0006310; Biological process:DNA recombination | |
Features
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| From: PS51899 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Tyr recombinase Flp-type #" | |||||||||
| ACT_SITE | 207 | 207 | /note="O-(3'-phospho-DNA)-tyrosine intermediate" | Y | ||||||||
Additional information
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| Size range | 280-290 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [6] All [ 6 ]
- Retrieve set of proteins with 3D structure for this domain