ProRule PRU01247

General rule information [?]

Accession PRU01247
Dates 3-JUL-2019 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Name Flp-type tyrosine recombinase domain
Function The yeast Flp recombinase is a tyrosine site-specific recombinase responsible for the control of plasmid copy number. All members of the tyrosine, or lambda integrase family of site-specific recombinases proceed via a 3' covalent phosphotyrosine intermediate to catalyze a variety of DNA rearrangements, including insertions, deletions, and inversions, depending on the location and orientation of cognate recombination target sites.
Scope(s) Eukaryota
Example(s) P13769 (FLP_ZYGBA);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the 'phage' integrase family.

Keywords [?]

Gene Ontology [?]

case <FT:2>
GO:0015074; Biological process:DNA integration
GO:0006310; Biological process:DNA recombination

Features [?]

From: PS51899
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Tyr recombinase Flp-type #"
ACT_SITE 207 207 /note="O-(3'-phospho-DNA)-tyrosine intermediate" Y

Additional information [?]

Size range 280-290 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]