ProRule PRU01247
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01247 |
| Accession | PRU01247 |
| Dates | 3-JUL-2019 (Created)
22-NOV-2019 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51899; TYR_RECOMBINASE_FLP |
Name | Flp-type tyrosine recombinase domain |
| Function | The yeast Flp recombinase is a tyrosine site-specific recombinase responsible for the control of plasmid copy number. All members of the tyrosine, or lambda integrase family of site-specific recombinases proceed via a 3' covalent phosphotyrosine intermediate to catalyze a variety of DNA rearrangements, including insertions, deletions, and inversions, depending on the location and orientation of cognate recombination target sites. |
| Scope(s) |
Eukaryota Saccharomycetaceae |
| Example(s) | P13769 (FLP_ZYGBA); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the 'phage' integrase family. |
Keywords
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| DNA integration | |
| DNA recombination | |
| end case | |
Gene Ontology
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| case <FT:2> | |
| GO:0015074; Biological process:DNA integration | |
| GO:0006310; Biological process:DNA recombination | |
Features
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| From: PS51899 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Tyr recombinase Flp-type #" | |||||||||
| ACT_SITE | 207 | 207 | /note="O-(3'-phospho-DNA)-tyrosine intermediate" | Y | ||||||||
Additional information
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| Size range | 280-290 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [6] All [ 6 ]
- Retrieve set of proteins with 3D structure for this domain