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ProRule PRU01250


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PURL: https://purl.expasy.org/prosite/rule/PRU01250
General rule information [?]

Accession PRU01250
Dates 15-AUG-2019 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51902; CLPX_ZB
Name ClpX zinc binding (ZB) domain
Function ClpX consists of an NH(2)-terminal zinc binding (ZB) domain that is involved in substrate and cofactor recognition and a AAA(+) domain that arranges into a hexamer in an ATP-dependent manner. The ClpX ZB domain contains the characteristic pattern C-X(2)-C-X(18)-C-X(2)-C of four cysteine residues and forms a constitutive dimer that is essential for the degradation of some ClpX substrates such as lambdaO and MuA but is not required for the degradation of other substrates such as green fluorescent protein SsrA.
Scope(s) Bacteria
Eukaryota
Euarchontoglires
Example(s) Q6G177 (CLPX_BARQU);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the ClpX chaperone family.

Keywords [?]

Metal-binding
Zinc
end case
Chaperone

Gene Ontology [?]

GO:0051082; Molecular function:unfolded protein binding
GO:0006457; Biological process:protein folding
case <FTGroup:1>
GO:0046983; Molecular function:protein dimerization activity
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51902
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ClpX-type ZB #"
BINDING 13 13 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 16 16 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 35 35 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 38 38 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 45-60 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]