ProRule PRU01250

Accession	PRU01250
Dates	15-AUG-2019 (Created) 19-NOV-2022 (Last updated, Version 4)
Data class	Domain;
Predictors	PROSITE; PS51902; CLPX_ZB
Name	ClpX zinc binding (ZB) domain
Function	ClpX consists of an NH(2)-terminal zinc binding (ZB) domain that is involved in substrate and cofactor recognition and a AAA(+) domain that arranges into a hexamer in an ATP-dependent manner. The ClpX ZB domain contains the characteristic pattern C-X(2)-C-X(18)-C-X(2)-C of four cysteine residues and forms a constitutive dimer that is essential for the degradation of some ClpX substrates such as lambdaO and MuA but is not required for the degradation of other substrates such as green fluorescent protein SsrA.
Scope(s)	Bacteria Eukaryota Euarchontoglires
Example(s)	Q6G177 (CLPX_BARQU);

From: PS51902
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="ClpX-type ZB #"
BINDING	13	13	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"		C	1
BINDING	16	16	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"		C	1
BINDING	35	35	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"		C	1
BINDING	38	38	/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"		C	1