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annotation rule: PRU01266

General rule information [?]

Accession PRU01266
Dates 20-MAR-2020 (Created)
20-MAR-2020 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51918; RADICAL_SAM
Name Radical SAM core domain
Function The radical SAM enzymes biochemically characterized to date have in common the cleavage of the [4Fe-4S]1+-SAM complex to [4Fe-4S]2+-Met and the 5'-deoxyadenosyl radical, which abstracts a hydrogen atom from the substrate to initiate a radical mechanism.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Cofactor [4Fe-4S] cluster

Gene Ontology [?]

GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

Features [?]

From: PS51918
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Radical SAM core #        
METAL     15     15       Iron-sulfur (4Fe-4S-S-AdoMet)     C   1
METAL     19     19       Iron-sulfur (4Fe-4S-S-AdoMet)     C   1
METAL     22     22       Iron-sulfur (4Fe-4S-S-AdoMet)     C   1

Additional information [?]

Size range 200-300 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5YT08 (MIAB_NOCFA)
Comments None


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UniProtKB rule member sequences [?]