We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01269
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01269
General rule information
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| Accession | PRU01269 |
| Dates | 27-MAR-2020 (Created)
30-SEP-2022 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51921; BCOV_S1_CTD |
Name | Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain |
| Function | The receptor binding domain (RBD) of betaCoV that directly engages the receptor is commonly located in the C-terminal half of S1 [C-terminal domain (CTD)] such as in SARS-CoV, SARS-CoV-2, MERS-CoV,and BatCoV HKU4, though in rare cases such as with mouse hepatitis virus (MHV), the RBD region was identified in the S1 N-terminal domain (NTD). |
| Scope(s) |
Viruses Betacoronavirus |
| Example(s) | P25194; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the betacoronaviruses spike protein family. |
Keywords
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Gene Ontology
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| GO:0016020; Cellular component:membrane |
| GO:0019064; Biological process:fusion of virus membrane with host plasma membrane |
| GO:0044173; Cellular component:host cell endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO:0075509; Biological process:endocytosis involved in viral entry into host cell |
| GO:0055036; Cellular component:virion membrane |
| GO:0046813; Biological process:receptor-mediated virion attachment to host cell |
| GO:0019031; Cellular component:viral envelope |
| GO:0039654; Biological process:fusion of virus membrane with host endosome membrane |
| GO:0020002; Cellular component:host cell plasma membrane |
Features
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| From: PS51921 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="BetaCoV S1-CTD #" | |||||||||
| DISULFID | 3 | 28 | disulf | C-x*-C | ||||||||
| DISULFID | 46 | 99 | disulf | C-x*-C | ||||||||
| DISULFID | 58 | 218 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 150-300 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Viruses [31] All [ 31 ]
- Retrieve set of proteins with 3D structure for this domain