ProRule PRU01283
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01283 |
| Accession | PRU01283 |
| Dates | 6-AUG-2020 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51934; LRAT |
Name | LRAT domain |
| Function | The NlpC/P60 LRAT-type family includes lecithin-retinol acyltransferase (LRAT), nematode developmental regulator Egl-26, class II tumor suppressor H-rev107 and proteins from poxviruses and animal positive- strand RNA viruses, which share a common catalytic domain fold and an unconventional active site. Several members of the NlpC/P60 LRAT-type family are able to act as transferases/esterases utilizing glycerophospholipids as acyl donors. |
| Scope(s) |
Eukaryota Euarchontoglires |
| Example(s) | Q9JI61 (LRAT_RAT); |
Propagated annotation
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Features
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| From: PS51934 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="LRAT #" | |||||||||
| ACT_SITE | 11 | 11 | H | 1 | ||||||||
| ACT_SITE | 23 | 23 | H | 1 | ||||||||
| ACT_SITE | 102 | 102 | /note="Acyl-thioester intermediate" | C | 1 | |||||||
Additional information
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| Size range | 85-155 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [23] Viruses [8] All [ 31 ]
- Retrieve set of proteins with 3D structure for this domain