PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01283


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01283
General rule information [?]

Accession PRU01283
Dates 06-AUG-2020 (Created)
06-AUG-2020 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51934; LRAT
Name LRAT domain
Function The NlpC/P60 LRAT-type family includes lecithin-retinol acyltransferase (LRAT), nematode developmental regulator Egl-26, class II tumor suppressor H-rev107 and proteins from poxviruses and animal positive- strand RNA viruses, which share a common catalytic domain fold and an unconventional active site. Several members of the NlpC/P60 LRAT-type family are able to act as transferases/esterases utilizing glycerophospholipids as acyl donors.
Scope(s) Eukaryota
Euarchontoglires
Example(s) Q9JI61;

Propagated annotation [?]

Features [?]

From: PS51934
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="LRAT #"
ACT_SITE 11 11 H 1
ACT_SITE 23 23 H 1
ACT_SITE 102 102 /note="Acyl-thioester intermediate" C 1

Additional information [?]

Size range 85-155 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]