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| annotation rule: PRU01283 |
General rule information
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| Accession | PRU01283 |
| Dates | 6-AUG-2020 (Created) 6-AUG-2020 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51934; LRAT |
| Name | LRAT domain |
| Function | The NlpC/P60 LRAT-type family includes lecithin-retinol acyltransferase (LRAT), nematode developmental regulator Egl-26, class II tumor suppressor H-rev107 and proteins from poxviruses and animal positive- strand RNA viruses, which share a common catalytic domain fold and an unconventional active site. Several members of the NlpC/P60 LRAT-type family are able to act as transferases/esterases utilizing glycerophospholipids as acyl donors. |
Propagated annotation
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Features
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| From: PS51934 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | LRAT # | |||||||||
| ACT_SITE | 11 | 11 | H | 1 | ||||||||
| ACT_SITE | 23 | 23 | H | 1 | ||||||||
| ACT_SITE | 102 | 102 | Acyl-thioester intermediate | C | 1 | |||||||
Additional information
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| Size range | 85-155 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q9JI61 (LRAT_RAT) |
| Scope | Eukaryota; Euarchontoglires |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [21] Viruses [7] All [ 28 ]
- Retrieve set of proteins with 3D structure for this domain