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General rule information [?]

Accession PRU01283
Dates 6-AUG-2020 (Created)
6-AUG-2020 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51934; LRAT
Name LRAT domain
Function The NlpC/P60 LRAT-type family includes lecithin-retinol acyltransferase (LRAT), nematode developmental regulator Egl-26, class II tumor suppressor H-rev107 and proteins from poxviruses and animal positive- strand RNA viruses, which share a common catalytic domain fold and an unconventional active site. Several members of the NlpC/P60 LRAT-type family are able to act as transferases/esterases utilizing glycerophospholipids as acyl donors.

Propagated annotation [?]

Features [?]

From: PS51934
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       LRAT #        
ACT_SITE     11     11             H   1
ACT_SITE     23     23             H   1
ACT_SITE     102     102       Acyl-thioester intermediate     C   1

Additional information [?]

Size range 85-155 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9JI61 (LRAT_RAT)
Eukaryota; Euarchontoglires
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]