ProRule PRU01304

General rule information [?]

Accession PRU01304
Dates 29-JAN-2021 (Created)
13-FEB-2023 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51959; ENDOU
Name Eukaryotic uridylate-specific endoribonuclease (EndoU) domain
Function The EndoU domain cleaves RNA at uridylates and release 2',3'-cyclic phosphodiester ends.
Scope(s) Eukaryota
Example(s) A8E627 (ENDUD_XENLA);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=3.1.-.-;

Comments [?]

FUNCTIONEndoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
SIMILARITYBelongs to the ENDOU family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0003723; Molecular function:RNA binding
GO:0004521; Molecular function:RNA endonuclease activity
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51959
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="EndoU #"
ACT_SITE 149 149 H 1
ACT_SITE 164 164 H 1
ACT_SITE 207 207 K 1

Additional information [?]

Size range 260-280 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]