ProRule PRU01304
General rule information
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| Accession | PRU01304 |
| Dates | 29-JAN-2021 (Created)
13-FEB-2023 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51959; ENDOU |
Name | Eukaryotic uridylate-specific endoribonuclease (EndoU) domain |
| Function | The EndoU domain cleaves RNA at uridylates and release 2',3'-cyclic phosphodiester ends. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | A8E627 (ENDUD_XENLA); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=3.1.-.-; |
Comments
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| FUNCTION | Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the ENDOU family. |
Keywords
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Gene Ontology
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| case <FTGroup:1> | |
| GO:0003723; Molecular function:RNA binding | |
| GO:0004521; Molecular function:RNA endonuclease activity | |
| GO:0046872; Molecular function:metal ion binding | |
Features
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| From: PS51959 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="EndoU #" | |||||||||
| ACT_SITE | 149 | 149 | H | 1 | ||||||||
| ACT_SITE | 164 | 164 | H | 1 | ||||||||
| ACT_SITE | 207 | 207 | K | 1 | ||||||||
Additional information
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| Size range | 260-280 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [15] All [ 15 ]
- Retrieve set of proteins with 3D structure for this domain