We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01304
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01304
General rule information
[?]
| Accession | PRU01304 |
| Dates | 29-JAN-2021 (Created)
13-FEB-2023 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51959; ENDOU |
Name | Eukaryotic uridylate-specific endoribonuclease (EndoU) domain |
| Function | The EndoU domain cleaves RNA at uridylates and release 2',3'-cyclic phosphodiester ends. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | A8E627; |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name | + RecName: EC=3.1.-.-; |
Comments
[?]
| FUNCTION | Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the ENDOU family. |
Keywords
[?]
Gene Ontology
[?]
| case <FTGroup:1> | |
| GO:0003723; Molecular function:RNA binding | |
| GO:0004521; Molecular function:RNA endonuclease activity | |
| GO:0046872; Molecular function:metal ion binding | |
Features
[?]
| From: PS51959 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="EndoU #" | |||||||||
| ACT_SITE | 149 | 149 | H | 1 | ||||||||
| ACT_SITE | 164 | 164 | H | 1 | ||||||||
| ACT_SITE | 207 | 207 | K | 1 | ||||||||
Additional information
[?]
| Size range | 260-280 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [15] All [ 15 ]
- Retrieve set of proteins with 3D structure for this domain