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annotation rule: PRU01313

General rule information [?]

Accession PRU01313
Dates 23-MAR-2021 (Created)
23-MAR-2021 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS51968; GRH_CP2_DB
Name Grh/CP2 DNA-binding (DB) domain
Function Grh/CP2 transcription factors (TFs) are highly conserved in multicellular organisms as key regulators of epithelial differentiation, organ development and skin barrier formation. Members of this TF family are widely found in diverse taxa, ranging from fungi to animals. All Grh/CP2 family members share a common domain architecture characterized by an intrinsically unstructured N-terminal transactivation domain (TAD), a conserved DNA-binding domain (DBD), also termed CP2 binding domain, and a C- terminal dimerization domain (DD).

Propagated annotation [?]

Comments [?]

Subcellular location Nucleus.

Gene Ontology [?]

GO:0005634; Cellular component: nucleus.

Keywords [?]

Features [?]

From: PS51968
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Grh/CP2 DB #        

Additional information [?]

Size range 225-245 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5RAR8 (GRHL1_PONAB)
Eukaryota; Metazoa
Comments None


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UniProtKB rule member sequences [?]