ProRule PRU01313
General rule information
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| Accession | PRU01313 |
| Dates | 23-MAR-2021 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51968; GRH_CP2_DB |
Name | Grh/CP2 DNA-binding (DB) domain |
| Function | Grh/CP2 transcription factors (TFs) are highly conserved in multicellular organisms as key regulators of epithelial differentiation, organ development and skin barrier formation. Members of this TF family are widely found in diverse taxa, ranging from fungi to animals. All Grh/CP2 family members share a common domain architecture characterized by an intrinsically unstructured N-terminal transactivation domain (TAD), a conserved DNA-binding domain (DBD), also termed CP2 binding domain, and a C- terminal dimerization domain (DD). |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q5RAR8 (GRHL1_PONAB); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
Keywords
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Gene Ontology
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| GO:0005634; Cellular component:nucleus |
Features
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| From: PS51968 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Grh/CP2 DB #" | |||||||||
Additional information
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| Size range | 225-245 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [23] All [ 23 ]
- Retrieve set of proteins with 3D structure for this domain