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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01313


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01313
General rule information [?]

Accession PRU01313
Dates 23-MAR-2021 (Created)
23-MAR-2021 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51968; GRH_CP2_DB
Name Grh/CP2 DNA-binding (DB) domain
Function Grh/CP2 transcription factors (TFs) are highly conserved in multicellular organisms as key regulators of epithelial differentiation, organ development and skin barrier formation. Members of this TF family are widely found in diverse taxa, ranging from fungi to animals. All Grh/CP2 family members share a common domain architecture characterized by an intrinsically unstructured N-terminal transactivation domain (TAD), a conserved DNA-binding domain (DBD), also termed CP2 binding domain, and a C- terminal dimerization domain (DD).
Scope(s) Eukaryota
Metazoa
Example(s) Q5RAR8;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

DNA-binding
Nucleus

Gene Ontology [?]

GO:0005634; Cellular component:nucleus

Features [?]

From: PS51968
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Grh/CP2 DB #"

Additional information [?]

Size range 225-245 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]