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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01322


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PURL: https://purl.expasy.org/prosite/rule/PRU01322
General rule information [?]

Accession PRU01322
Dates 16-JUN-2021 (Created)
16-JUN-2021 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51978; PBC
Name PBC domain
Function The PBC class of TALE homeodomain proteins includes the products of the vertebrate Pbx1, Pbx2, Pbx3 and Pbx4, Caenorhabditis elegans ceh-20, ceh-40 and ceh-60 and the Drosophila extradenticle (exd) genes. The sequence similarity between the PBC proteins extends downstream of the homeodomain for about 15 amino acids, and upstream of the homeodomain is a 180-amino acid dimerization domain termed PBC. The PBC domain can be further subdivided into an A and B region.
Scope(s) Eukaryota
Metazoa
Example(s) Q6IR52;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.
SIMILARITYBelongs to the TALE/PBX homeobox family.

Keywords [?]

Nucleus

Features [?]

From: PS51978
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PBC #"
REGION 8 89 /note="PBC-A #"
REGION 92 188 /note="PBC-B #"

Additional information [?]

Size range 175-205 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]