ProRule PRU01322
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01322 |
| Accession | PRU01322 |
| Dates | 16-JUN-2021 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51978; PBC |
Name | PBC domain |
| Function | The PBC class of TALE homeodomain proteins includes the products of the vertebrate Pbx1, Pbx2, Pbx3 and Pbx4, Caenorhabditis elegans ceh-20, ceh-40 and ceh-60 and the Drosophila extradenticle (exd) genes. The sequence similarity between the PBC proteins extends downstream of the homeodomain for about 15 amino acids, and upstream of the homeodomain is a 180-amino acid dimerization domain termed PBC. The PBC domain can be further subdivided into an A and B region. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q6IR52 (PBX2_XENLA); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the TALE/PBX homeobox family. |
Keywords
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Features
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| From: PS51978 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PBC #" | |||||||||
| REGION | 8 | 89 | /note="PBC-A #" | |||||||||
| REGION | 92 | 188 | /note="PBC-B #" | |||||||||
Additional information
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| Size range | 175-205 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [18] All [ 18 ]
- Retrieve set of proteins with 3D structure for this domain