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ProRule PRU01332


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01332
Accession PRU01332
Dates 8-OCT-2021 (Created)
19-NOV-2022 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51988; HERPESVIRUS_UL32
Name Herpesviridae UL32 packaging protein family
Function The Herpesviridae UL32 family proteins form homopentameric rings with a positively charged central channel that binds double-stranded DNA.
Scope(s) Viruses
Herpesviridae
Example(s) Q66671 (UL32_EHV2);

Propagated annotation [?]

Comments [?]

FUNCTIONPlays a role in efficient localization of neo- synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.
SIMILARITYBelongs to the herpesviridae UL32 protein family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger
Host cytoplasm
Host nucleus

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0030430; Cellular component:host cell cytoplasm
GO:0019031; Cellular component:viral envelope
case (<Feature:PS51988:67=CH> and <Feature:PS51988:70=CH> and <Feature:PS51988:145=HC> and <Feature:PS51988:151=CH>) or (<Feature:PS51988:220=CH> and <Feature:PS51988:221=CH> and <Feature:PS51988:445=HC> and <Feature:PS51988:483=CH>) or (<Feature:PS51988:328=CH> and <Feature:PS51988:331=CH> and <Feature:PS51988:398=HC> and <Feature:PS51988:405=CH>)
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51988
Key From To Description Tag Condition FTGroup
case <FTGroup:1>
REGION 67 151 /note="Zinc finger #1"
end case
case <FTGroup:3>
REGION 220 483 /note="Zinc finger #3"
end case
case <FTGroup:2>
REGION 328 405 /note="Zinc finger #2"
end case
BINDING 67 67 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 70 70 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 145 145 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 151 151 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 220 220 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 221 221 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 328 328 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 331 331 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 398 398 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 405 405 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 445 445 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 483 483 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3

Additional information [?]

Size range 430-620 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]