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annotation rule: PRU01332

General rule information [?]

Accession PRU01332
Dates 8-OCT-2021 (Created)
14-MAY-2022 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51988; HERPESVIRUS_UL32
Name Herpesviridae UL32 packaging protein family
Function The Herpesviridae UL32 family proteins form homopentameric rings with a positively charged central channel that binds double-stranded DNA.

Propagated annotation [?]


Comments [?]

Function Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.
Similarity Belongs to the herpesviridae UL32 protein family.

Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0030430; Cellular component: host cell cytoplasm.
GO:0019031; Cellular component: viral envelope.
case (<Feature:PS51988:67=CH> and <Feature:PS51988:70=CH> and <Feature:PS51988:145=HC> and <Feature:PS51988:151=CH>) or (<Feature:PS51988:220=CH> and <Feature:PS51988:221=CH> and <Feature:PS51988:445=HC> and <Feature:PS51988:483=CH>) or (<Feature:PS51988:328=CH> and <Feature:PS51988:331=CH> and <Feature:PS51988:398=HC> and <Feature:PS51988:405=CH>)
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Metal-binding
Zinc
end case

Zinc-finger
Host cytoplasm
Host nucleus

Features [?]

case <FTGroup:1>
From: PS51988
Key     From     To       Description   Tag   Condition   FTGroup
REGION     67     151       Zinc finger #1        
end case

case <FTGroup:3>
REGION     220     483       Zinc finger #3        
end case

case <FTGroup:2>
REGION     328     405       Zinc finger #2        
end case

BINDING     67     67       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   1
BINDING     70     70       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   1
BINDING     145     145       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   1
BINDING     151     151       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   1
BINDING     220     220       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     [CH]   3
BINDING     221     221       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     [CH]   3
BINDING     328     328       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     [CH]   2
BINDING     331     331       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     [CH]   2
BINDING     398     398       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     [CH]   2
BINDING     405     405       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#2     [CH]   2
BINDING     445     445       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     [CH]   3
BINDING     483     483       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#3     [CH]   3

Additional information [?]

Size range 430-620 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q66671 (UL32_EHV2)
Scope
Viruses; Herpesviridae
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]