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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01332


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01332
General rule information [?]

Accession PRU01332
Dates 08-OCT-2021 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51988; HERPESVIRUS_UL32
Name Herpesviridae UL32 packaging protein family
Function The Herpesviridae UL32 family proteins form homopentameric rings with a positively charged central channel that binds double-stranded DNA.
Scope(s) Viruses
Herpesviridae
Example(s) Q66671;

Propagated annotation [?]

Comments [?]

FUNCTIONPlays a role in efficient localization of neo- synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA.
SIMILARITYBelongs to the herpesviridae UL32 protein family.

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger
Host cytoplasm
Host nucleus

Gene Ontology [?]

GO:0042025; Cellular component:host cell nucleus
GO:0030430; Cellular component:host cell cytoplasm
GO:0019031; Cellular component:viral envelope
case (<Feature:PS51988:67=CH> and <Feature:PS51988:70=CH> and <Feature:PS51988:145=HC> and <Feature:PS51988:151=CH>) or (<Feature:PS51988:220=CH> and <Feature:PS51988:221=CH> and <Feature:PS51988:445=HC> and <Feature:PS51988:483=CH>) or (<Feature:PS51988:328=CH> and <Feature:PS51988:331=CH> and <Feature:PS51988:398=HC> and <Feature:PS51988:405=CH>)
GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51988
Key From To Description Tag Condition FTGroup
case <FTGroup:1>
REGION 67 151 /note="Zinc finger #1"
end case
case <FTGroup:3>
REGION 220 483 /note="Zinc finger #3"
end case
case <FTGroup:2>
REGION 328 405 /note="Zinc finger #2"
end case
BINDING 67 67 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 70 70 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 145 145 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 151 151 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 220 220 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 221 221 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 328 328 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 331 331 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 398 398 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 405 405 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 445 445 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3
BINDING 483 483 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [CH] 3

Additional information [?]

Size range 430-620 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]