ProRule logo

General rule information [?]

Accession PRU01339
Dates 18-MAR-2022 (Created)
13-JAN-2023 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51995; ATLF
Name Anthrax toxin lethal factor (ATLF)-like domain
Function The ATLF-like domain acts either as a metalloprotease domain, forming the M34 family of metalloendopeptidases, (ATLF domain IV, PPEP-1 and 2) or as an anthrax protective antigen-binding domain (PABD) (ATLF domain I and EF and Certhrax PABD).

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit
Similarity Belongs to the peptidase M34 family.

Gene Ontology [?]

GO:0008237; Molecular function: metallopeptidase activity.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

Features [?]

From: PS51995
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ATLF-like #        
ACT_SITE     111     111       Proton acceptor     E   1
BINDING     110     110       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     114     114       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     147     147       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     Y   1
BINDING     154     154       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     E   1

Additional information [?]

Size range 180-230 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q183R7 (PPEP1_CLOD6)
Bacteria; Bacillota
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]