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ProRule PRU01339


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01339
Accession PRU01339
Dates 18-MAR-2022 (Created)
13-JAN-2023 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51995; ATLF
Name Anthrax toxin lethal factor (ATLF)-like domain
Function The ATLF-like domain acts either as a metalloprotease domain, forming the M34 family of metalloendopeptidases, (ATLF domain IV, PPEP-1 and 2) or as an anthrax protective antigen-binding domain (PABD) (ATLF domain I and EF and Certhrax PABD).
Scope(s) Bacteria
Bacillota
Example(s) Q183R7 (PPEP1_CLOD6);

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.
SIMILARITYBelongs to the peptidase M34 family.

Keywords [?]

Metal-binding
Zinc
Hydrolase
Protease
Metalloprotease
end case

Gene Ontology [?]

GO:0008237; Molecular function:metallopeptidase activity
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51995
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ATLF-like #"
ACT_SITE 111 111 /note="Proton acceptor" E 1
BINDING 110 110 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1
BINDING 114 114 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1
BINDING 147 147 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 Y 1
BINDING 154 154 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 E 1

Additional information [?]

Size range 180-230 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]