PRU01339

General rule information [?]

Accession	PRU01339
Dates	18-MAR-2022 (Created) 13-JAN-2023 (Last updated, Version 4)

Data class

Domain

Predictors

PROSITE; PS51995; ATLF

Name	Anthrax toxin lethal factor (ATLF)-like domain

Function

The ATLF-like domain acts either as a metalloprotease domain, forming the M34 family of metalloendopeptidases, (ATLF domain IV, PPEP-1 and 2) or as an anthrax protective antigen-binding domain (PABD) (ATLF domain I and EF and Certhrax PABD).

Propagated annotation [?]

Comments [?]

case <FTGroup:1>

Cofactor	Zn(2+) Note: Binds 1 zinc ion per subunit
Similarity	Belongs to the peptidase M34 family.

Gene Ontology [?]

GO:0008237; Molecular function: metallopeptidase activity.
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Metal-binding
Zinc
Hydrolase
Protease
Metalloprotease

end case

Features [?]

From: PS51995

Key From To Description Tag Condition FTGroup

DOMAIN from to ATLF-like #

ACT_SITE 111 111 Proton acceptor E 1

BINDING 110 110 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 114 114 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 147 147 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic Y 1

BINDING 154 154 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic E 1

Additional information [?]

Size range	180-230 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q183R7 (PPEP1_CLOD6)
Scope	Bacteria; Bacillota
Comments	None

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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Bacteria [5]
Retrieve set of proteins with 3D structure for this domain