We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01339
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01339
General rule information
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| Accession | PRU01339 |
| Dates | 18-MAR-2022 (Created)
13-JAN-2023 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51995; ATLF |
Name | Anthrax toxin lethal factor (ATLF)-like domain |
| Function | The ATLF-like domain acts either as a metalloprotease domain, forming the M34 family of metalloendopeptidases, (ATLF domain IV, PPEP-1 and 2) or as an anthrax protective antigen-binding domain (PABD) (ATLF domain I and EF and Certhrax PABD). |
| Scope(s) |
Bacteria Bacillota |
| Example(s) | Q183R7; |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit. |
| SIMILARITY | Belongs to the peptidase M34 family. |
Keywords
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| Metal-binding | |
| Zinc | |
| Hydrolase | |
| Protease | |
| Metalloprotease | |
| end case | |
Gene Ontology
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| GO:0008237; Molecular function:metallopeptidase activity |
| GO:0046872; Molecular function:metal ion binding |
Features
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| From: PS51995 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ATLF-like #" | |||||||||
| ACT_SITE | 111 | 111 | /note="Proton acceptor" | E | 1 | |||||||
| BINDING | 110 | 110 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 114 | 114 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 147 | 147 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
Y | 1 | |||||||
| BINDING | 154 | 154 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
E | 1 | |||||||
Additional information
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| Size range | 180-230 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain