PRU01339
General rule information
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Accession | PRU01339 |
Dates | 18-MAR-2022 (Created) 13-JAN-2023 (Last updated, Version 4) |
Data class | Domain |
Predictors | PROSITE; PS51995; ATLF |
Name | Anthrax toxin lethal factor (ATLF)-like domain |
Function | The ATLF-like domain acts either as a metalloprotease domain, forming the M34 family of metalloendopeptidases, (ATLF domain IV, PPEP-1 and 2) or as an anthrax protective antigen-binding domain (PABD) (ATLF domain I and EF and Certhrax PABD). |
Propagated annotation
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Comments
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case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit |
Similarity | Belongs to the peptidase M34 family. |
Gene Ontology
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GO:0008237; Molecular function: metallopeptidase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0046872; Molecular function: metal ion binding.
Keywords
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end case
Features
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From: PS51995 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | ATLF-like # | |||||||||
ACT_SITE | 111 | 111 | Proton acceptor | E | 1 | |||||||
BINDING | 110 | 110 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 114 | 114 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 147 | 147 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | Y | 1 | |||||||
BINDING | 154 | 154 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | E | 1 |
Additional information
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Size range | 180-230 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q183R7 (PPEP1_CLOD6) |
Scope | Bacteria; Bacillota |
Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Bacteria [5]
- Retrieve set of proteins with 3D structure for this domain