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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01353


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01353
General rule information [?]

Accession PRU01353
Dates 21-NOV-2022 (Created)
21-NOV-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52009; GH84
Name Glycosyl hydrolases family 84 (GH84) domain
Function Family 84 glycoside hydrolases (GH84) cleave the glycosidic linkage of N-acetylglucosaminides by a two-step catalytic mechanism that involves a pair of aspartate residues as catalytic residues, D1 as the polarizing residue and Asp175 as the general acid/base catalyst.
Scope(s) Bacteria
Eukaryota
Euarchontoglires
Example(s) Q89ZI2;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.2.1.-;
end case

Comments [?]

SIMILARITYBelongs to the glycosyl hydrolase 84 family.

Keywords [?]

case <FTGroup:1>
Glycosidase
Hydrolase
end case

Features [?]

From: PS52009
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GH84 #"
ACT_SITE 117 117 /note="Proton donor" D 1

Additional information [?]

Size range 268-282 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]