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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01355


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01355
General rule information [?]

Accession PRU01355
Dates 05-DEC-2022 (Created)
05-DEC-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52011; PEPTIDASE_M2
Name Peptidase family M2 domain
Function Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (EC 3.4.15.1, ACE, peptidyl-dipeptidase A), play important roles in regulating a number of physiological processes.
Scope(s) Eukaryota
Metazoa
Example(s) Q56NL1;

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTORName=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case
SIMILARITYBelongs to the peptidase M2 family.

Keywords [?]

Carboxypeptidase
Hydrolase
Protease
end case
case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
Metalloprotease
end case
case (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
Metal-binding
end case
case <FTGroup:2>
Zinc
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
GO:0008237; Molecular function:metallopeptidase activity
end case
case (<FTGroup:1>)
GO:0008241; Molecular function:peptidyl-dipeptidase activity
GO:0004180; Molecular function:carboxypeptidase activity

Features [?]

From: PS52011
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase M2 #"
ACT_SITE 350 350 /note="Proton acceptor #1" E 1
ACT_SITE 479 479 /note="Proton donor #1" H 1
BINDING 349 349 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 353 353 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 377 377 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 E 2
BINDING 152 152 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#1"		 R 3
BINDING 451 451 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#1"		 W 3
BINDING 455 455 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#1"		 [RK] 3
case <Feature:PS52011:373=[P]> and <Feature:PS52011:485=[P]>
BINDING 190 190 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#2"		 Y 4
BINDING 488 488 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#2"		 R 4
end case
DISULFID 115 123 disulf C-x*-C
DISULFID 318 336 disulf C-x*-C
DISULFID 504 522 disulf C-x*-C

Additional information [?]

Size range 580-591 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]