General rule information
[?]
Accession |
PRU01355 |
Dates |
5-DEC-2022 (Created) 5-DEC-2022 (Last updated, Version 1) |
Predictors |
PROSITE; PS52011; PEPTIDASE_M2
|
Name |
Peptidase family M2 domain |
Function |
Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (EC 3.4.15.1, ACE, peptidyl-dipeptidase A), play important roles in regulating a number of physiological processes. |
Propagated annotation
[?]
case <FTGroup:2>
end case
Similarity |
Belongs to the peptidase M2 family. |
case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
GO:0008237; Molecular function: metallopeptidase activity.
end case
case (<FTGroup:1>)
GO:0008241; Molecular function: peptidyl-dipeptidase activity.
GO:0004180; Molecular function: carboxypeptidase activity.
end case
case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
end case
case (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
end case
case <FTGroup:2>
end case
case <FTTag:disulf>
end case
From: PS52011 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
Peptidase M2 #
|
|
|
|
|
|
|
ACT_SITE
|
|
350
|
|
350
|
|
Proton acceptor #1
|
|
|
|
E
|
|
1
|
ACT_SITE
|
|
479
|
|
479
|
|
Proton donor #1
|
|
|
|
H
|
|
1
|
BINDING
|
|
349
|
|
349
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic
|
|
|
|
H
|
|
2
|
BINDING
|
|
353
|
|
353
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic
|
|
|
|
H
|
|
2
|
BINDING
|
|
377
|
|
377
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic
|
|
|
|
E
|
|
2
|
BINDING
|
|
152
|
|
152
|
|
/ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1
|
|
|
|
R
|
|
3
|
BINDING
|
|
451
|
|
451
|
|
/ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1
|
|
|
|
W
|
|
3
|
BINDING
|
|
455
|
|
455
|
|
/ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1
|
|
|
|
[RK]
|
|
3
|
case <Feature:PS52011:373=[P]> and <Feature:PS52011:485=[P]>
BINDING
|
|
190
|
|
190
|
|
/ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2
|
|
|
|
Y
|
|
4
|
BINDING
|
|
488
|
|
488
|
|
/ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2
|
|
|
|
R
|
|
4
|
end case
DISULFID
|
|
115
|
|
123
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
318
|
|
336
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
504
|
|
522
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
Additional information
[?]
Size range |
580-591 amino acids |
Related rules |
None |
Repeats |
1-2 |
Topology |
Undefined |
Example |
Q56NL1 (ACE2_PAGLA) |
Scope |
Eukaryota; Metazoa |
Comments |
None |
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