ProRule logo

General rule information [?]

Accession PRU01355
Dates 5-DEC-2022 (Created)
5-DEC-2022 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52011; PEPTIDASE_M2
Name Peptidase family M2 domain
Function Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (EC, ACE, peptidyl-dipeptidase A), play important roles in regulating a number of physiological processes.

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
Cofactor Zn(2+)
end case

Similarity Belongs to the peptidase M2 family.

Gene Ontology [?]

case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
GO:0008237; Molecular function: metallopeptidase activity.
end case

case (<FTGroup:1>)
GO:0008241; Molecular function: peptidyl-dipeptidase activity.
GO:0004180; Molecular function: carboxypeptidase activity.

Keywords [?]

end case

case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
end case

case (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
end case

case <FTGroup:2>
end case

case <FTTag:disulf>
end case

Features [?]

From: PS52011
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase M2 #        
ACT_SITE     350     350       Proton acceptor #1     E   1
ACT_SITE     479     479       Proton donor #1     H   1
BINDING     349     349       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic     H   2
BINDING     353     353       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic     H   2
BINDING     377     377       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic     E   2
BINDING     152     152       /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1     R   3
BINDING     451     451       /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1     W   3
BINDING     455     455       /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1     [RK]   3
case <Feature:PS52011:373=[P]> and <Feature:PS52011:485=[P]>
BINDING     190     190       /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2     Y   4
BINDING     488     488       /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2     R   4
end case

DISULFID     115     123           disulf   C-x*-C  
DISULFID     318     336           disulf   C-x*-C  
DISULFID     504     522           disulf   C-x*-C  

Additional information [?]

Size range 580-591 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example Q56NL1 (ACE2_PAGLA)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]