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ProRule PRU01355


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU01355
Accession PRU01355
Dates 5-DEC-2022 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52011; PEPTIDASE_M2
Name Peptidase family M2 domain
Function Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (EC 3.4.15.1, ACE, peptidyl-dipeptidase A), play important roles in regulating a number of physiological processes.
Scope(s) Eukaryota
Metazoa
Example(s) Q56NL1 (ACE2_PAGLA);

Propagated annotation [?]

Comments [?]

case <FTGroup:2>
COFACTORName=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case
SIMILARITYBelongs to the peptidase M2 family.

Keywords [?]

Carboxypeptidase
Hydrolase
Protease
end case
case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
Metalloprotease
end case
case (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
Metal-binding
end case
case <FTGroup:2>
Zinc
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
GO:0008237; Molecular function:metallopeptidase activity
end case
case (<FTGroup:1>)
GO:0008241; Molecular function:peptidyl-dipeptidase activity
GO:0004180; Molecular function:carboxypeptidase activity

Features [?]

From: PS52011
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase M2 #"
ACT_SITE 350 350 /note="Proton acceptor #1" E 1
ACT_SITE 479 479 /note="Proton donor #1" H 1
BINDING 349 349 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 353 353 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 2
BINDING 377 377 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 E 2
BINDING 152 152 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#1"		 R 3
BINDING 451 451 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#1"		 W 3
BINDING 455 455 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#1"		 [RK] 3
case <Feature:PS52011:373=[P]> and <Feature:PS52011:485=[P]>
BINDING 190 190 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#2"		 Y 4
BINDING 488 488 /ligand="chloride"
/ligand_id="ChEBI:CHEBI:17996"
/ligand_label="#2"		 R 4
end case
DISULFID 115 123 disulf C-x*-C
DISULFID 318 336 disulf C-x*-C
DISULFID 504 522 disulf C-x*-C

Additional information [?]

Size range 580-591 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]