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| annotation rule: PRU01355 |
General rule information
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| Accession | PRU01355 |
| Dates | 5-DEC-2022 (Created) 5-DEC-2022 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS52011; PEPTIDASE_M2 |
| Name | Peptidase family M2 domain |
| Function | Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (EC 3.4.15.1, ACE, peptidyl-dipeptidase A), play important roles in regulating a number of physiological processes. |
Propagated annotation
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Comments
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case <FTGroup:2>
| Cofactor | Zn(2+) |
end case
| Similarity | Belongs to the peptidase M2 family. |
Gene Ontology
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case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
GO:0008237; Molecular function: metallopeptidase activity.
end case
case (<FTGroup:1>)
GO:0008241; Molecular function: peptidyl-dipeptidase activity.
GO:0004180; Molecular function: carboxypeptidase activity.
GO:0004180; Molecular function: carboxypeptidase activity.
Keywords
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end case
case (<FTGroup:1>) and (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
end case
case (<FTGroup:2> or <FTGroup:3> or <FTGroup:4>)
end case
case <FTGroup:2>
end case
case <FTTag:disulf>
end case
Features
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| From: PS52011 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Peptidase M2 # | |||||||||
| ACT_SITE | 350 | 350 | Proton acceptor #1 | E | 1 | |||||||
| ACT_SITE | 479 | 479 | Proton donor #1 | H | 1 | |||||||
| BINDING | 349 | 349 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic | H | 2 | |||||||
| BINDING | 353 | 353 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic | H | 2 | |||||||
| BINDING | 377 | 377 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /ligand_note="catalytic | E | 2 | |||||||
| BINDING | 152 | 152 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1 | R | 3 | |||||||
| BINDING | 451 | 451 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1 | W | 3 | |||||||
| BINDING | 455 | 455 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1 | [RK] | 3 | |||||||
case <Feature:PS52011:373=[P]> and <Feature:PS52011:485=[P]>
| BINDING | 190 | 190 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2 | Y | 4 | |||||||
| BINDING | 488 | 488 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2 | R | 4 |
end case
Additional information
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| Size range | 580-591 amino acids |
| Related rules | None |
| Repeats | 1-2 |
| Topology | Undefined |
| Example | Q56NL1 (ACE2_PAGLA) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
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