We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01360
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01360
General rule information
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| Accession | PRU01360 |
| Dates | 31-JAN-2023 (Created)
03-FEB-2023 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52016; TONB_DEPENDENT_REC_3 |
Name | TonB-dependent receptor proteins |
| Function | TonB-dependent receptors (TBDRs) are transport proteins found at the outer membrane (OM) to allow Gram-negative bacteria to uptake scarce resources from competitive environments with very high affinity. All of them share the same basic architecture, a C-terminal membrane-embedded 22-strand antiparallel beta-barrel domain that is sealed by a conserved N-terminal globular 'plug' domain (also called 'cork' or 'hatch'). |
| Scope(s) |
Bacteria |
| Example(s) | Q9KVI9; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Cell outer membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the TonB-dependent receptor family. |
Keywords
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Gene Ontology
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| GO:0009279; Cellular component:cell outer membrane |
Cross-references
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Features
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| From: PS52016 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | 119 | /note="TBDR plug #" | |||||||||
| DOMAIN | 124 | to | /note="TBDR beta-barrel #" | |||||||||
Additional information
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| Size range | 80-1001 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [126] All [ 126 ]
- Retrieve set of proteins with 3D structure for this domain