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General rule information [?]

Accession PRU01363
Dates 3-MAR-2023 (Created)
3-MAR-2023 (Last updated, Version 1)
Data class Domain
Predictors PROSITE; PS52019; PKS_MFAS_DH
Name Polyketide and metazoan fatty acid synthase dehydratase (PKS/mFAS DH) domain
Function Dehydratase domains catalyze formation of an alpha,beta-double bond in the nascent polyketide intermediate.

Propagated annotation [?]

Features [?]

From: PS52019
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PKS/mFAS DH #        
REGION     from     132       N-terminal hotdog fold #        
REGION     149     to       C-terminal hotdog fold #        
ACT_SITE     33     33       Proton acceptor; for dehydratase activity #     H   1
ACT_SITE     210     210       Proton donor; for dehydratase activity #     D   1

Additional information [?]

Size range 261-345 amino acids
Related rules None
Repeats 1-3
Topology Undefined
Example Q54FQ1 (PKS31_DICDI)
Comments None


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