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ProRule PRU01363
General rule information
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| Accession | PRU01363 |
| Dates | 3-MAR-2023 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52019; PKS_MFAS_DH |
Name | Polyketide and metazoan fatty acid synthase dehydratase (PKS/mFAS DH) domain |
| Function | Dehydratase domains catalyze formation of an alpha,beta-double bond in the nascent polyketide intermediate. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q54FQ1 (PKS31_DICDI); |
Propagated annotation
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Features
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| From: PS52019 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PKS/mFAS DH #" | |||||||||
| REGION | from | 132 | /note="N-terminal hotdog fold #" | |||||||||
| REGION | 149 | to | /note="C-terminal hotdog fold #" | |||||||||
| ACT_SITE | 33 | 33 | /note="Proton acceptor; for dehydratase activity #" | H | 1 | |||||||
| ACT_SITE | 210 | 210 | /note="Proton donor; for dehydratase activity #" | D | 1 | |||||||
Additional information
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| Size range | 261-345 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-3 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [33] Eukaryota [370] All [ 403 ]
- Retrieve set of proteins with 3D structure for this domain