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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01363


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01363
General rule information [?]

Accession PRU01363
Dates 03-MAR-2023 (Created)
03-MAR-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52019; PKS_MFAS_DH
Name Polyketide and metazoan fatty acid synthase dehydratase (PKS/mFAS DH) domain
Function Dehydratase domains catalyze formation of an alpha,beta-double bond in the nascent polyketide intermediate.
Scope(s) Eukaryota
Bacteria
Example(s) Q54FQ1;

Propagated annotation [?]

Features [?]

From: PS52019
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PKS/mFAS DH #"
REGION from 132 /note="N-terminal hotdog fold #"
REGION 149 to /note="C-terminal hotdog fold #"
ACT_SITE 33 33 /note="Proton acceptor; for dehydratase activity #" H 1
ACT_SITE 210 210 /note="Proton donor; for dehydratase activity #" D 1

Additional information [?]

Size range 261-345 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]