ProRule PRU01363

General rule information [?]

Accession PRU01363
Dates 3-MAR-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS52019; PKS_MFAS_DH
Name Polyketide and metazoan fatty acid synthase dehydratase (PKS/mFAS DH) domain
Function Dehydratase domains catalyze formation of an alpha,beta-double bond in the nascent polyketide intermediate.
Scope(s) Eukaryota
Example(s) Q54FQ1 (PKS31_DICDI);

Propagated annotation [?]

Features [?]

From: PS52019
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PKS/mFAS DH #"
REGION from 132 /note="N-terminal hotdog fold #"
REGION 149 to /note="C-terminal hotdog fold #"
ACT_SITE 33 33 /note="Proton acceptor; for dehydratase activity #" H 1
ACT_SITE 210 210 /note="Proton donor; for dehydratase activity #" D 1

Additional information [?]

Size range 261-345 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]