ProRule PRU01386
General rule information
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| Accession | PRU01386 |
| Dates | 6-DEC-2023 (Created)
-- (Last updated, Version 1) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52042; GLOBIN_CP_ADGB |
Name | Androglobin (Adgb) circularly permuted globin domain |
| Function | Adgb has a unique modular architecture, possessing an N-terminal calpain-like domain, an internal, circular permuted globin domain, and an IQ calmodulin-binding motif. |
| Scope(s) |
Eukaryota Euarchontoglires |
| Example(s) | G3UZ78 (ADGB_MOUSE); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Androglobin; |
Comments
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| DOMAIN | The globin domain is circularly permuted. The globin domain, which normally consists of eight consecutive alpha-helices from A (N-terminal) to H (C-terminal), is circularly permutated and split into two parts. The part containing helices A and B is shifted C-terminally and is separated from the main globin sequence (helices C-H) by a potential calmodulin-binding IQ domain. |
| SIMILARITY | In the central section; belongs to the globin family. |
Keywords
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| case <FTGroup:1> | |
| Iron | |
| Metal-binding | |
| end case | |
| Heme | |
Gene Ontology
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| GO:0020037; Molecular function:heme binding |
Cross-references
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| PROSITE | PS50096; IQ; 1; |
Features
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| From: PS52042 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | from | 131 | /note="Globin domain; C-terminal part" | |||||||||
| REGION | 179 | to | /note="Globin domain; N-terminal part" | |||||||||
| BINDING | 30 | 30 | /ligand="heme b" /ligand_id="ChEBI:CHEBI:60344" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="distal binding residue" |
[QH] | 1 | |||||||
| BINDING | 62 | 62 | /ligand="heme b" /ligand_id="ChEBI:CHEBI:60344" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="proximal binding residue" |
H | 1 | |||||||
Additional information
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| Size range | 206-206 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [2] All [ 2 ]
- Retrieve set of proteins with 3D structure for this domain