ProRule PRU01386

General rule information [?]

Accession PRU01386
Dates 6-DEC-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Name Androglobin (Adgb) circularly permuted globin domain
Function Adgb has a unique modular architecture, possessing an N-terminal calpain-like domain, an internal, circular permuted globin domain, and an IQ calmodulin-binding motif.
Scope(s) Eukaryota
Example(s) G3UZ78 (ADGB_MOUSE);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Androglobin;

Comments [?]

DOMAINThe globin domain is circularly permuted. The globin domain, which normally consists of eight consecutive alpha-helices from A (N-terminal) to H (C-terminal), is circularly permutated and split into two parts. The part containing helices A and B is shifted C-terminally and is separated from the main globin sequence (helices C-H) by a potential calmodulin-binding IQ domain.
SIMILARITYIn the central section; belongs to the globin family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0020037; Molecular function:heme binding

Cross-references [?]

PROSITE PS50096; IQ; 1;

Features [?]

From: PS52042
Key From To Description Tag Condition FTGroup
REGION from 131 /note="Globin domain; C-terminal part"
REGION 179 to /note="Globin domain; N-terminal part"
BINDING 30 30 /ligand="heme b"
/note="distal binding residue"
[QH] 1
BINDING 62 62 /ligand="heme b"
/note="proximal binding residue"
H 1

Additional information [?]

Size range 206-206 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]