We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01386
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01386
General rule information
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| Accession | PRU01386 |
| Dates | 06-DEC-2023 (Created)
06-DEC-2023 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52042; GLOBIN_CP_ADGB |
Name | Androglobin (Adgb) circularly permuted globin domain |
| Function | Adgb has a unique modular architecture, possessing an N-terminal calpain-like domain, an internal, circular permuted globin domain, and an IQ calmodulin-binding motif. |
| Scope(s) |
Eukaryota Euarchontoglires |
| Example(s) | G3UZ78; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Androglobin; |
Comments
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| DOMAIN | The globin domain is circularly permuted. The globin domain, which normally consists of eight consecutive alpha-helices from A (N-terminal) to H (C-terminal), is circularly permutated and split into two parts. The part containing helices A and B is shifted C-terminally and is separated from the main globin sequence (helices C-H) by a potential calmodulin-binding IQ domain. |
| SIMILARITY | In the central section; belongs to the globin family. |
Keywords
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| case <FTGroup:1> | |
| Iron | |
| Metal-binding | |
| end case | |
| Heme | |
Gene Ontology
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| GO:0020037; Molecular function:heme binding |
Cross-references
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| PROSITE | PS50096; IQ; 1; |
Features
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| From: PS52042 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | from | 131 | /note="Globin domain; C-terminal part" | |||||||||
| REGION | 179 | to | /note="Globin domain; N-terminal part" | |||||||||
| BINDING | 30 | 30 | /ligand="heme b" /ligand_id="ChEBI:CHEBI:60344" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="distal binding residue" |
[QH] | 1 | |||||||
| BINDING | 62 | 62 | /ligand="heme b" /ligand_id="ChEBI:CHEBI:60344" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="proximal binding residue" |
H | 1 | |||||||
Additional information
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| Size range | 206-206 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [2] All [ 2 ]
- Retrieve set of proteins with 3D structure for this domain