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ProRule PRU01390


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PURL: https://purl.expasy.org/prosite/rule/PRU01390
General rule information [?]

Accession PRU01390
Dates 07-JUN-2024 (Created)
28-JUN-2024 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS52045; NEPROSIN_PEP_CD
Name Neprosin prolyl endopeptidase (PEP) catalytic domain
Function Neprosin is a prolyl endoprotease (PEP), which preferentially cleaves C-terminal to proline residues under highly acidic conditions.
Scope(s) Eukaryota
Nepenthes
Example(s) C0HLV2 (NEPRN_NEPVE);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.21.26;

Comments [?]

CATALYTIC ACTIVITYReaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.; EC=3.4.21.26;
SIMILARITYBelongs to the peptidase G3 family.
end case

Keywords [?]

Hydrolase
Protease
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0070012; Molecular function:oligopeptidase activity
GO:0006508; Biological process:proteolysis
GO:0004175; Molecular function:endopeptidase activity

Features [?]

From: PS52045
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Neprosin PEP catalytic #"
ACT_SITE 60 60 E 1
ACT_SITE 172 172 E 1
DISULFID 91 96 disulf C-x*-C
DISULFID 228 251 disulf C-x*-C

Additional information [?]

Size range 252-252 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]