We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01390
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01390
General rule information
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| Accession | PRU01390 |
| Dates | 07-JUN-2024 (Created)
28-JUN-2024 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52045; NEPROSIN_PEP_CD |
Name | Neprosin prolyl endopeptidase (PEP) catalytic domain |
| Function | Neprosin is a prolyl endoprotease (PEP), which preferentially cleaves C-terminal to proline residues under highly acidic conditions. |
| Scope(s) |
Eukaryota Nepenthes |
| Example(s) | C0HLV2; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.4.21.26; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.; EC=3.4.21.26; |
| SIMILARITY | Belongs to the peptidase G3 family. |
| end case | |
Keywords
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| Hydrolase | |
| Protease | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0070012; Molecular function:oligopeptidase activity | |
| GO:0006508; Biological process:proteolysis | |
| GO:0004175; Molecular function:endopeptidase activity | |
Features
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| From: PS52045 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Neprosin PEP catalytic #" | |||||||||
| ACT_SITE | 60 | 60 | E | 1 | ||||||||
| ACT_SITE | 172 | 172 | E | 1 | ||||||||
| DISULFID | 91 | 96 | disulf | C-x*-C | ||||||||
| DISULFID | 228 | 251 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 252-252 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [1] All [ 1 ]
- Retrieve set of proteins with 3D structure for this domain